Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging

D Ilver, A Arnqvist, J Ogren, Inga-Maria Frick, D Kersulyte, E T Incecik, D E Berg, A Covacci, L Engstrand, T Boren

Research output: Contribution to journalArticlepeer-review

Abstract

The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.
Original languageEnglish
Pages (from-to)373-377
JournalScience
Volume279
Issue number5349
DOIs
Publication statusPublished - 1998

Subject classification (UKÄ)

  • Infectious Medicine

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