Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation

Jafar Mahdavi; Berit Sondén; Marina Hurtig; Farzad O. Olfat; Lina Forsberg; Niamh Roche; Jonas Ångström; Thomas Larsson; Susann Teneberg; Karl-Anders Karlsson; Siiri Altraja; Torkel Wadström; Dangeruta Kersulyte; Douglas E. Berg; Andre Dubois; Christoffer Petersson; Karl-Eric Magnusson; Thomas Norberg; Frank Lindh; Bertil B. Lundskog; Anna Arnqvist; Lennart Hammarström; Thomas Borén

doi:10.1126/science.1069076

Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation

Jafar Mahdavi, Berit Sondén, Marina Hurtig, Farzad O. Olfat, Lina Forsberg, Niamh Roche, Jonas Ångström, Thomas Larsson, Susann Teneberg, Karl-Anders Karlsson, Siiri Altraja, Torkel Wadström, Dangeruta Kersulyte, Douglas E. Berg, Andre Dubois, Christoffer Petersson, Karl-Eric Magnusson, Thomas Norberg, Frank Lindh, Bertil B. LundskogAnna Arnqvist, Lennart Hammarström, Thomas Borén

Research output: Contribution to journal › Article › peer-review

243 Downloads (Pure)

Abstract

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

Original language	English
Pages (from-to)	573-578
Journal	Science
Volume	297
Issue number	5581
DOIs	https://doi.org/10.1126/science.1069076
Publication status	Published - 2002

Subject classification (UKÄ)

Microbiology in the medical area

Access to Document

10.1126/science.1069076

mahdavi_etal_Science_2002

Cite this

Mahdavi, J., Sondén, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., Ångström, J., Larsson, T., Teneberg, S., Karlsson, K.-A., Altraja, S., Wadström, T., Kersulyte, D., Berg, D. E., Dubois, A., Petersson, C., Magnusson, K.-E., Norberg, T., Lindh, F., ... Borén, T. (2002). Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science, 297(5581), 573-578. https://doi.org/10.1126/science.1069076

@article{25cbbce1801e4548b5a8810c4cb0d949,

title = "Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation",

abstract = "Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the {"}retagging{"} method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.",

author = "Jafar Mahdavi and Berit Sond{\'e}n and Marina Hurtig and Olfat, {Farzad O.} and Lina Forsberg and Niamh Roche and Jonas {\AA}ngstr{\"o}m and Thomas Larsson and Susann Teneberg and Karl-Anders Karlsson and Siiri Altraja and Torkel Wadstr{\"o}m and Dangeruta Kersulyte and Berg, {Douglas E.} and Andre Dubois and Christoffer Petersson and Karl-Eric Magnusson and Thomas Norberg and Frank Lindh and Lundskog, {Bertil B.} and Anna Arnqvist and Lennart Hammarstr{\"o}m and Thomas Bor{\'e}n",

year = "2002",

doi = "10.1126/science.1069076",

language = "English",

volume = "297",

pages = "573--578",

journal = "Science",

issn = "1095-9203",

publisher = "American Association for the Advancement of Science (AAAS)",

number = "5581",

}

Mahdavi, J, Sondén, B, Hurtig, M, Olfat, FO, Forsberg, L, Roche, N, Ångström, J, Larsson, T, Teneberg, S, Karlsson, K-A, Altraja, S, Wadström, T, Kersulyte, D, Berg, DE, Dubois, A, Petersson, C, Magnusson, K-E, Norberg, T, Lindh, F, Lundskog, BB, Arnqvist, A, Hammarström, L & Borén, T 2002, 'Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation', Science, vol. 297, no. 5581, pp. 573-578. https://doi.org/10.1126/science.1069076

TY - JOUR

T1 - Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation

AU - Mahdavi, Jafar

AU - Sondén, Berit

AU - Hurtig, Marina

AU - Olfat, Farzad O.

AU - Forsberg, Lina

AU - Roche, Niamh

AU - Ångström, Jonas

AU - Larsson, Thomas

AU - Teneberg, Susann

AU - Karlsson, Karl-Anders

AU - Altraja, Siiri

AU - Wadström, Torkel

AU - Kersulyte, Dangeruta

AU - Berg, Douglas E.

AU - Dubois, Andre

AU - Petersson, Christoffer

AU - Magnusson, Karl-Eric

AU - Norberg, Thomas

AU - Lindh, Frank

AU - Lundskog, Bertil B.

AU - Arnqvist, Anna

AU - Hammarström, Lennart

AU - Borén, Thomas

PY - 2002

Y1 - 2002

N2 - Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

AB - Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

U2 - 10.1126/science.1069076

DO - 10.1126/science.1069076

M3 - Article

SN - 1095-9203

VL - 297

SP - 573

EP - 578

JO - Science

JF - Science

IS - 5581

ER -

Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Cite this