Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.

Adam Linder; Ryan Arnold; John H Boyd; Marko Zindovic; Igor Zindovic; Anna Lange; Magnus Paulsson; Patrik Nyberg; James A Russell; David Pritchard; Bertil Christensson; Per Åkesson

doi:10.1097/CCM.0000000000001265

Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.

Adam Linder, Ryan Arnold, John H Boyd, Marko Zindovic, Igor Zindovic, Anna Lange, Magnus Paulsson, Patrik Nyberg, James A Russell, David Pritchard, Bertil Christensson, Per Åkesson

Linköping University Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Early identification of patients with infection and at risk of developing severe disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a multicenter setting.

Original language	English
Pages (from-to)	2378-2386
Journal	Critical Care Medicine
Volume	43
Issue number	11
DOIs	https://doi.org/10.1097/CCM.0000000000001265
Publication status	Published - 2015

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Thoracic Surgery (013230027), Faculty of Medicine (000022000), Clinical Microbiology, Malmö (013011000), Division of Infection Medicine (SUS) (013008000)

Subject classification (UKÄ)

Anesthesiology and Intensive Care

Access to Document

10.1097/CCM.0000000000001265

http://www.ncbi.nlm.nih.gov/pubmed/26468696?dopt=Abstract

Cite this

Linder, A., Arnold, R., Boyd, J. H., Zindovic, M., Zindovic, I., Lange, A., Paulsson, M., Nyberg, P., Russell, J. A., Pritchard, D., Christensson, B., & Åkesson, P. (2015). Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department. Critical Care Medicine, 43(11), 2378-2386. https://doi.org/10.1097/CCM.0000000000001265

@article{aa529a3d0ddc45dab61403cb3a0b96e7,

title = "Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.",

abstract = "Early identification of patients with infection and at risk of developing severe disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a multicenter setting.",

author = "Adam Linder and Ryan Arnold and Boyd, {John H} and Marko Zindovic and Igor Zindovic and Anna Lange and Magnus Paulsson and Patrik Nyberg and Russell, {James A} and David Pritchard and Bertil Christensson and Per {\AA}kesson",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Thoracic Surgery (013230027), Faculty of Medicine (000022000), Clinical Microbiology, Malm{\"o} (013011000), Division of Infection Medicine (SUS) (013008000)",

year = "2015",

doi = "10.1097/CCM.0000000000001265",

language = "English",

volume = "43",

pages = "2378--2386",

journal = "Critical Care Medicine",

issn = "1530-0293",

publisher = "Lippincott Williams & Wilkins",

number = "11",

}

Linder, A, Arnold, R, Boyd, JH, Zindovic, M, Zindovic, I, Lange, A, Paulsson, M, Nyberg, P, Russell, JA, Pritchard, D, Christensson, B & Åkesson, P 2015, 'Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.', Critical Care Medicine, vol. 43, no. 11, pp. 2378-2386. https://doi.org/10.1097/CCM.0000000000001265

TY - JOUR

T1 - Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.

AU - Linder, Adam

AU - Arnold, Ryan

AU - Boyd, John H

AU - Zindovic, Marko

AU - Zindovic, Igor

AU - Lange, Anna

AU - Paulsson, Magnus

AU - Nyberg, Patrik

AU - Russell, James A

AU - Pritchard, David

AU - Christensson, Bertil

AU - Åkesson, Per

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Thoracic Surgery (013230027), Faculty of Medicine (000022000), Clinical Microbiology, Malmö (013011000), Division of Infection Medicine (SUS) (013008000)

PY - 2015

Y1 - 2015

N2 - Early identification of patients with infection and at risk of developing severe disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a multicenter setting.

AB - Early identification of patients with infection and at risk of developing severe disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a multicenter setting.

U2 - 10.1097/CCM.0000000000001265

DO - 10.1097/CCM.0000000000001265

M3 - Article

C2 - 26468696

SN - 1530-0293

VL - 43

SP - 2378

EP - 2386

JO - Critical Care Medicine

JF - Critical Care Medicine

IS - 11

ER -

Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.

Abstract

Bibliographical note

Subject classification (UKÄ)

Access to Document

Fingerprint

Cite this