Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Kaixin Zhou; Louise Donnelly; Jian Yang; Miaoxin Li; Harshal Deshmukh; Natalie Van Zuydam; Emma Ahlqvist; Chris C Spencer; Leif Groop; Andrew D Morris; Helen M Colhoun; Pak C Sham; Mark I McCarthy; Colin N A Palmer; Ewan R Pearson

doi:10.1016/S2213-8587(14)70050-6

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Kaixin Zhou, Louise Donnelly, Jian Yang, Miaoxin Li, Harshal Deshmukh, Natalie Van Zuydam, Emma Ahlqvist, Chris C Spencer, Leif Groop, Andrew D Morris, Helen M Colhoun, Pak C Sham, Mark I McCarthy, Colin N A Palmer, Ewan R Pearson

Research output: Contribution to journal › Article › peer-review

Abstract

Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.

Original language	English
Pages (from-to)	481-487
Journal	The Lancet Diabetes & Endocrinology
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/S2213-8587(14)70050-6
Publication status	Published - 2014

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S2213-8587(14)70050-6

http://www.ncbi.nlm.nih.gov/pubmed/24731673?dopt=Abstract

Cite this

Zhou, K., Donnelly, L., Yang, J., Li, M., Deshmukh, H., Van Zuydam, N., Ahlqvist, E., Spencer, C. C., Groop, L., Morris, A. D., Colhoun, H. M., Sham, P. C., McCarthy, M. I., Palmer, C. N. A., & Pearson, E. R. (2014). Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis. The Lancet Diabetes & Endocrinology, 2(6), 481-487. https://doi.org/10.1016/S2213-8587(14)70050-6

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title = "Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.",

abstract = "Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.",

author = "Kaixin Zhou and Louise Donnelly and Jian Yang and Miaoxin Li and Harshal Deshmukh and {Van Zuydam}, Natalie and Emma Ahlqvist and Spencer, {Chris C} and Leif Groop and Morris, {Andrew D} and Colhoun, {Helen M} and Sham, {Pak C} and McCarthy, {Mark I} and Palmer, {Colin N A} and Pearson, {Ewan R}",

year = "2014",

doi = "10.1016/S2213-8587(14)70050-6",

language = "English",

volume = "2",

pages = "481--487",

journal = "The Lancet Diabetes & Endocrinology",

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Zhou, K, Donnelly, L, Yang, J, Li, M, Deshmukh, H, Van Zuydam, N, Ahlqvist, E, Spencer, CC, Groop, L, Morris, AD, Colhoun, HM, Sham, PC, McCarthy, MI, Palmer, CNA & Pearson, ER 2014, 'Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.', The Lancet Diabetes & Endocrinology, vol. 2, no. 6, pp. 481-487. https://doi.org/10.1016/S2213-8587(14)70050-6

TY - JOUR

T1 - Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

AU - Zhou, Kaixin

AU - Donnelly, Louise

AU - Yang, Jian

AU - Li, Miaoxin

AU - Deshmukh, Harshal

AU - Van Zuydam, Natalie

AU - Ahlqvist, Emma

AU - Spencer, Chris C

AU - Groop, Leif

AU - Morris, Andrew D

AU - Colhoun, Helen M

AU - Sham, Pak C

AU - McCarthy, Mark I

AU - Palmer, Colin N A

AU - Pearson, Ewan R

PY - 2014

Y1 - 2014

N2 - Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.

AB - Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.

U2 - 10.1016/S2213-8587(14)70050-6

DO - 10.1016/S2213-8587(14)70050-6

M3 - Article

SN - 2213-8595

VL - 2

SP - 481

EP - 487

JO - The Lancet Diabetes & Endocrinology

JF - The Lancet Diabetes & Endocrinology

IS - 6

ER -

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Abstract

Subject classification (UKÄ)

UN SDGs

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