Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

Johan Sundelof, Johan Sundstrom, Oskar Hansson, Maria Eriksdotter-Jonhagen, Vilmantas Giedraitis, Anders Larsson, Malin Degerman-Gunnarsson, Martin Ingelsson, Lennart Minthon, Kaj Blennow, Lena Kilander, Hans Basun, Lars Lannfelt

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59 Citations (SciVal)

Abstract

Cathepsin B is suggested to be involved in amyloid-beta (A beta) processing and Alzheimer's disease (AD). Studies of cathepsin B levels in plasma and cerebrospinal fluid (CSF) have not been previously performed. We examined cathepsin B levels in plasma and CSF samples in persons with AD, mild cognitive impairment (MCI), and healthy controls in order to test the hypothesis that cathepsin B levels can discriminate persons with AD or MCI from healthy controls. Cathepsin B, Cystatin C, A beta(1-40) and A beta(1-42), total tau, phosphorylated tau, and albumin levels in plasma and CSF were analyzed by ELISA (Cathepsin B) turbidimetry (cystatin C), xMAP Luminex technology (A beta(1-40) and A beta(1-42) and tau), and Cobas C501 analyzer (albumin) in persons with AD (n=101), MCI (n - 84), and healthy control subjects (n - 28). Plasma cathepsin B levels were higher in persons with AD compared to healthy controls, both in unadjusted models and in multivariable models adjusting for age, gender, APOE genotype, cystatin C, and albumin levels: Odds ratio (OR) for AD per 1 SD of plasma cathepsin B; 2.04, 95% confidence interval (CI); 1.01-4.14, p = 0.05. There was no difference between diagnostic groups in cathepsin B levels in CSF: OR for AD per 1 SD of CSF cathepsin B; 0.93, 95% CI; 0.37-2.30, p = 0.87. Plasma cathepsin B levels were higher in persons with AD compared to healthy controls whereas there was no difference between diagnostic groups in cathepsin B levels in CSF. Further investigation of cathepsin B as a predictor of AD is warranted.
Original languageEnglish
Pages (from-to)1223-1230
JournalJournal of Alzheimer's Disease
Volume22
Issue number4
DOIs
Publication statusPublished - 2010

Subject classification (UKÄ)

  • Neurology

Keywords

  • risk factor
  • epidemiology
  • cystatin C
  • cathepsin B
  • case control study
  • biomarkers
  • Alzheimer's disease

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