Highly increased familial risks for specific lymphoma subtypes

Lynn R. Goldin; Magnus Bjorkholm; Sigurdur Y. Kristinsson; Ingemar Turesson; Ola Landgren

doi:10.1111/j.1365-2141.2009.07721.x

Highly increased familial risks for specific lymphoma subtypes

Lynn R. Goldin, Magnus Bjorkholm, Sigurdur Y. Kristinsson, Ingemar Turesson, Ola Landgren

Department of Clinical Sciences, Malmö

Research output: Contribution to journal › Article › peer-review

Abstract

P>Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.

Original language	English
Pages (from-to)	91-94
Journal	British Journal of Haematology
Volume	146
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2141.2009.07721.x
Publication status	Published - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

Subject classification (UKÄ)

Hematology

Free keywords

non-Hodgkin lymphoma
diffuse large B-cell lymphoma
follicular
familial risk
lymphoma
Hodgkin lymphoma

Access to Document

10.1111/j.1365-2141.2009.07721.x

Cite this

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title = "Highly increased familial risks for specific lymphoma subtypes",

abstract = "P>Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.",

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note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)",

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doi = "10.1111/j.1365-2141.2009.07721.x",

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T1 - Highly increased familial risks for specific lymphoma subtypes

AU - Goldin, Lynn R.

AU - Bjorkholm, Magnus

AU - Kristinsson, Sigurdur Y.

AU - Turesson, Ingemar

AU - Landgren, Ola

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

PY - 2009

Y1 - 2009

N2 - P>Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.

AB - P>Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) patients compared to first-degree relatives of controls. Relatives were at the highest risk for developing the same lymphoma subtype as the case. DLBCL was increased 10-fold among relatives of DLBCL patients, FL was increased fourfold among relatives of FL patients and HL was increased fourfold among relatives of HL patients. These results imply that germline susceptibility genes are specific to lymphoma subtype.

KW - non-Hodgkin lymphoma

KW - diffuse large B-cell lymphoma

KW - follicular

KW - familial risk

KW - lymphoma

KW - Hodgkin lymphoma

U2 - 10.1111/j.1365-2141.2009.07721.x

DO - 10.1111/j.1365-2141.2009.07721.x

M3 - Article

SN - 0007-1048

VL - 146

SP - 91

EP - 94

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 1

ER -

Highly increased familial risks for specific lymphoma subtypes

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

Access to Document

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Cite this