HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma

Camilla Thuring; Elna Follin; Linda Geironson Ulfsson; Eva Freyhult; Victoria Junghans; Mikkel Harndahl; Søren Buus; Kajsa M Paulsson

doi:10.1038/bjc.2015.297

HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma

Camilla Thuring, Elna Follin, Linda Geironson Ulfsson, Eva Freyhult, Victoria Junghans, Mikkel Harndahl, Søren Buus, Kajsa M Paulsson

Research output: Contribution to journal › Article › peer-review

Abstract

Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.

Original language	English
Pages (from-to)	952-962
Journal	British Journal of Cancer
Volume	113
Issue number	6
DOIs	https://doi.org/10.1038/bjc.2015.297
Publication status	Published - 2015

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

HLA-I
tapasin
glioblastoma multiforme
peptide
tapasin-dependency
immunotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/bjc.2015.297

http://www.ncbi.nlm.nih.gov/pubmed/26313662?dopt=Abstract

Microscopy Community Lund University
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Cite this

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title = "HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma",

abstract = "Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.",

keywords = "HLA-I, tapasin, glioblastoma multiforme, peptide, tapasin-dependency, immunotherapy",

author = "Camilla Thuring and Elna Follin and {Geironson Ulfsson}, Linda and Eva Freyhult and Victoria Junghans and Mikkel Harndahl and S{\o}ren Buus and Paulsson, {Kajsa M}",

year = "2015",

doi = "10.1038/bjc.2015.297",

language = "English",

volume = "113",

pages = "952--962",

journal = "British Journal of Cancer",

issn = "1532-1827",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma

AU - Thuring, Camilla

AU - Follin, Elna

AU - Geironson Ulfsson, Linda

AU - Freyhult, Eva

AU - Junghans, Victoria

AU - Harndahl, Mikkel

AU - Buus, Søren

AU - Paulsson, Kajsa M

PY - 2015

Y1 - 2015

N2 - Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.

AB - Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours.

KW - HLA-I

KW - tapasin

KW - glioblastoma multiforme

KW - peptide

KW - tapasin-dependency

KW - immunotherapy

U2 - 10.1038/bjc.2015.297

DO - 10.1038/bjc.2015.297

M3 - Article

C2 - 26313662

SN - 1532-1827

VL - 113

SP - 952

EP - 962

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 6

ER -

HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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Microscopy Community Lund University

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