TY - JOUR
T1 - HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.
AU - Hadley, David
AU - Hagopian, William
AU - Liu, Edwin
AU - She, Jin-Xiong
AU - Simell, Olli
AU - Akolkar, Beena
AU - Ziegler, Anette-G
AU - Rewers, Marian
AU - Krischer, Jeffrey P
AU - Chen, Wei-Min
AU - Onengut-Gumuscu, Suna
AU - Bugawan, Teodorica L
AU - Rich, Stephen S
AU - Erlich, Henry
AU - Agardh, Daniel
PY - 2015
Y1 - 2015
N2 - Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen (HLA) factors other than DR3-DQ2 for their contribution to developing tTGAs.
AB - Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen (HLA) factors other than DR3-DQ2 for their contribution to developing tTGAs.
U2 - 10.1038/ajg.2015.150
DO - 10.1038/ajg.2015.150
M3 - Article
C2 - 26010309
SN - 1572-0241
VL - 110
SP - 915
EP - 920
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 6
ER -
