How should antibodies against P. falciparum merozoite antigens be measured?

S. Chuangchaiya, Kristina Persson

Research output: Contribution to journalReview articlepeer-review

110 Downloads (Pure)

Abstract

Immunity against malaria develops slowly and only after repeated exposure to the parasite. Many of those that die of the disease are children under five years of age. Antibodies are an important part of immunity, but which antibodies that are protective and how these should be measured are still unclear. We discuss the pros and cons of ELISA, invasion inhibition assays/ADCI, and measurement of affinity of antibodies and what can be done to improve these assays, thereby increasing the knowledge about the immune status of an individual, and to perform better evaluation of vaccine trials.
Original languageEnglish
Article number493834
JournalJournal of Tropical Medicine
DOIs
Publication statusPublished - 2013
Externally publishedYes

Subject classification (UKÄ)

  • Immunology in the medical area

Free keywords

  • antibody
  • antigen
  • malaria vaccine
  • merozoite antigen
  • unclassified drug

Fingerprint

Dive into the research topics of 'How should antibodies against P. falciparum merozoite antigens be measured?'. Together they form a unique fingerprint.

Cite this