hTERT T-1327/C polymorphism is not associated with age-related telomere attrition in peripheral blood

Katarina Nordfjall, Pia Osterman, Olle Melander, Peter Nilsson, Goran Roos

Research output: Contribution to journalArticlepeer-review

Abstract

Regulation of the telomerase catalytic subunit, hTERT, is a complex process accomplished on many levels. Transcription of the hTERT gene has been widely studied but less is known about the implication of genetic variations. Recently, a functional T to C transition polymorphisin was indicated 1327 bp upstream the hTERT transcription starting site. The C-1327/C genotype was associated with shorter telomere length compared to the alternative genotypes in healthy individuals and in coronary artery disease patients. We tested this observation and analysed telomere length and the T-1327/C polymorphism in 226 myocardial infarction patients and 444 controls from southern Sweden. No significant difference in telomere length was found among the genotypes after age adjustments in the control group (p = 0.794) or in the MI group (p = 0.339). Moreover, no increased age-related attrition was observed for the C-1327/C genotype as previously indicated, rather a telomere elongation in the control group (p = 0.021) not seen in the MI group (P = 0.249). (c) 2007 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)215-218
JournalBiochemical and Biophysical Research Communications
Volume358
Issue number1
DOIs
Publication statusPublished - 2007

Subject classification (UKÄ)

  • Biological Sciences

Free keywords

  • polymorphism
  • telomere length
  • hTERT
  • age
  • myocardial infarction

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