HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.

Johan Evenäs, Fredrik Edfeldt, Matti Lepistö, Naila Svitacheva, Anna Synnergren, Britta Lundquist, Mia Gränse, Anna Rönnholm, Mikael Varga, John Wright, Min Wei, Sherrie Yue, Junfeng Wang, Chong Li, Xuan Li, Gang Chen, Yong Liao, Gang Lv, Ann Tjörnebo, Frank Narjes

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Pharmacology, Toxicology and Pharmaceutical Science