Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating

Andreas Edsfeldt; Kristina Eriksson Stenström; Jiangming Sun; Nuno Dias; Göran Skog; Pratibha Singh; Sören Mattsson; Jan Nilsson; Isabel Gonçalves

doi:10.1016/j.jacbts.2021.08.005

Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating

Andreas Edsfeldt, Kristina Eriksson Stenström, Jiangming Sun, Nuno Dias, Göran Skog, Pratibha Singh, Sören Mattsson, Jan Nilsson, Isabel Gonçalves

Research output: Contribution to journal › Article › peer-review

Abstract

Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.

Original language	English
Pages (from-to)	734-745
Journal	JACC: Basic to Translational Science
Volume	6
Issue number	9-10
DOIs	https://doi.org/10.1016/j.jacbts.2021.08.005
Publication status	Published - 2021

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

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10.1016/j.jacbts.2021.08.005

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title = "Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating",

abstract = "Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression. ",

author = "Andreas Edsfeldt and {Eriksson Stenstr{\"o}m}, Kristina and Jiangming Sun and Nuno Dias and G{\"o}ran Skog and Pratibha Singh and S{\"o}ren Mattsson and Jan Nilsson and Isabel Gon{\c c}alves",

year = "2021",

doi = "10.1016/j.jacbts.2021.08.005",

language = "English",

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pages = "734--745",

journal = "JACC: Basic to Translational Science",

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TY - JOUR

T1 - Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating

AU - Edsfeldt, Andreas

AU - Eriksson Stenström, Kristina

AU - Sun, Jiangming

AU - Dias, Nuno

AU - Skog, Göran

AU - Singh, Pratibha

AU - Mattsson, Sören

AU - Nilsson, Jan

AU - Gonçalves, Isabel

PY - 2021

Y1 - 2021

N2 - Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.

AB - Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.

U2 - 10.1016/j.jacbts.2021.08.005

DO - 10.1016/j.jacbts.2021.08.005

M3 - Article

C2 - 34754987

SN - 2452-302X

VL - 6

SP - 734

EP - 745

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 9-10

ER -

Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating

Abstract

Subject classification (UKÄ)

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