Human immunoglobulin G levels of viruses and associated glioma risk

Sara Sjostrom, Ulf Hjalmars, Per Juto, Goran Wadell, Goran Hallmans, Anne Tjonneland, Jytte Halkjaer, Jonas Manjer, Martin Almquist, Beatrice S. Melin

Research output: Contribution to journalArticlepeer-review

22 Citations (SciVal)


Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR) = 0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p = 0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2 years before diagnosis (OR = 0.63, 95% CI 0.37-1.08) (p = 0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus.
Original languageEnglish
Pages (from-to)1259-1266
JournalCancer Causes and Control
Issue number9
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Cancer and Oncology


  • Glioma
  • Glioblastoma
  • Immunoglobulin G
  • Virus
  • Case-control study


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