Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Yuriy Pomeshchik; Oxana Klementieva; Jeovanis Gil; Isak Martinsson; Marita Grønning Hansen; Tessa de Vries; Anna Sancho-Balsells; Kaspar Russ; Ekaterina Savchenko; Anna Collin; Ana Rita Vaz; Silvia Bagnoli; Benedetta Nacmias; Claire Rampon; Sandro Sorbi; Dora Brites; György Marko-Varga; Zaal Kokaia; Melinda Rezeli; Gunnar K. Gouras; Laurent Roybon

doi:10.1016/j.stemcr.2020.06.001

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Grønning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, György Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K. GourasLaurent Roybon

Research output: Contribution to journal › Article › peer-review

Abstract

In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.

Original language	English
Pages (from-to)	256-273
Number of pages	18
Journal	Stem Cell Reports
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.stemcr.2020.06.001
Publication status	Published - 2020

Subject classification (UKÄ)

Neurosciences
Cell and Molecular Biology

Free keywords

Alzheimer disease
hippocampus
iPSC
NeuroD1
protein aggregation
proteomics
spheroids
transcriptomics
viral-mediated gene therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stemcr.2020.06.001

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Pomeshchik, Y., Klementieva, O., Gil, J., Martinsson, I., Hansen, M. G., de Vries, T., Sancho-Balsells, A., Russ, K., Savchenko, E., Collin, A., Vaz, A. R., Bagnoli, S., Nacmias, B., Rampon, C., Sorbi, S., Brites, D., Marko-Varga, G., Kokaia, Z., Rezeli, M., ... Roybon, L. (2020). Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies. Stem Cell Reports, 15(1), 256-273. https://doi.org/10.1016/j.stemcr.2020.06.001

@article{fd37f0d1d452414aba0c38b395cdbffc,

title = "Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies",

abstract = "In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.",

keywords = "Alzheimer disease, hippocampus, iPSC, NeuroD1, protein aggregation, proteomics, spheroids, transcriptomics, viral-mediated gene therapy",

author = "Yuriy Pomeshchik and Oxana Klementieva and Jeovanis Gil and Isak Martinsson and Hansen, {Marita Gr{\o}nning} and {de Vries}, Tessa and Anna Sancho-Balsells and Kaspar Russ and Ekaterina Savchenko and Anna Collin and Vaz, {Ana Rita} and Silvia Bagnoli and Benedetta Nacmias and Claire Rampon and Sandro Sorbi and Dora Brites and Gy{\"o}rgy Marko-Varga and Zaal Kokaia and Melinda Rezeli and Gouras, {Gunnar K.} and Laurent Roybon",

year = "2020",

doi = "10.1016/j.stemcr.2020.06.001",

language = "English",

volume = "15",

pages = "256--273",

journal = "Stem Cell Reports",

issn = "2213-6711",

publisher = "Cell Press",

number = "1",

}

Pomeshchik, Y , Klementieva, O , Gil, J , Martinsson, I, Hansen, MG, de Vries, T, Sancho-Balsells, A, Russ, K, Savchenko, E, Collin, A, Vaz, AR, Bagnoli, S, Nacmias, B, Rampon, C, Sorbi, S, Brites, D, Marko-Varga, G , Kokaia, Z , Rezeli, M , Gouras, GK & Roybon, L 2020, 'Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies', Stem Cell Reports, vol. 15, no. 1, pp. 256-273. https://doi.org/10.1016/j.stemcr.2020.06.001

TY - JOUR

T1 - Human iPSC-Derived Hippocampal Spheroids

T2 - An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

AU - Pomeshchik, Yuriy

AU - Klementieva, Oxana

AU - Gil, Jeovanis

AU - Martinsson, Isak

AU - Hansen, Marita Grønning

AU - de Vries, Tessa

AU - Sancho-Balsells, Anna

AU - Russ, Kaspar

AU - Savchenko, Ekaterina

AU - Collin, Anna

AU - Vaz, Ana Rita

AU - Bagnoli, Silvia

AU - Nacmias, Benedetta

AU - Rampon, Claire

AU - Sorbi, Sandro

AU - Brites, Dora

AU - Marko-Varga, György

AU - Kokaia, Zaal

AU - Rezeli, Melinda

AU - Gouras, Gunnar K.

AU - Roybon, Laurent

PY - 2020

Y1 - 2020

N2 - In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.

AB - In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.

KW - Alzheimer disease

KW - hippocampus

KW - iPSC

KW - NeuroD1

KW - protein aggregation

KW - proteomics

KW - spheroids

KW - transcriptomics

KW - viral-mediated gene therapy

UR - https://doi.org/10.1016/j.stemcr.2021.10.003

U2 - 10.1016/j.stemcr.2020.06.001

DO - 10.1016/j.stemcr.2020.06.001

M3 - Article

C2 - 32589876

AN - SCOPUS:85087499545

SN - 2213-6711

VL - 15

SP - 256

EP - 273

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 1

ER -

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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