Human pulmonary 3D models for translational research

Katja Zscheppang, Johanna Berg, Sarah Hedtrich, Leonie Verheyen, Darcy E Wagner, Norbert Suttorp, Stefan Hippenstiel, Andreas C Hocke

Research output: Contribution to journalReview articlepeer-review

Abstract

Lung diseases belong the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air-liquid interface cultures, precision cut lung slices as well as ex vivo cultures of explanted peripheral lung tissue and de-/re-cellularization models. Diseases such as asthma or infections are discussed and an outlook on further areas for development is given. Overall, the progress in ex vivo modelling by using primary human material could make translational research activities more efficient by simultaneously fostering the mechanistic understanding of human lung diseases while reducing animal usage in biomedical research.

Original languageEnglish
JournalBiotechnology Journal
Volume13
Issue number1
Early online date2017 Sept 2
DOIs
Publication statusPublished - 2018
Externally publishedYes

Free keywords

  • Journal Article
  • Review

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