TY - JOUR
T1 - Hydration for health hypothesis
T2 - a narrative review of supporting evidence
AU - Perrier, Erica T.
AU - Armstrong, Lawrence E.
AU - Bottin, Jeanne H.
AU - Clark, William F.
AU - Dolci, Alberto
AU - Guelinckx, Isabelle
AU - Iroz, Alison
AU - Kavouras, Stavros A.
AU - Lang, Florian
AU - Lieberman, Harris R.
AU - Melander, Olle
AU - Morin, Clementine
AU - Seksek, Isabelle
AU - Stookey, Jodi D.
AU - Tack, Ivan
AU - Vanhaecke, Tiphaine
AU - Vecchio, Mariacristina
AU - Péronnet, François
PY - 2021
Y1 - 2021
N2 - Purpose: An increasing body of evidence suggests that excreting a generous volume of diluted urine is associated with short- and long-term beneficial health effects, especially for kidney and metabolic function. However, water intake and hydration remain under-investigated and optimal hydration is poorly and inconsistently defined. This review tests the hypothesis that optimal chronic water intake positively impacts various aspects of health and proposes an evidence-based definition of optimal hydration. Methods: Search strategy included PubMed and Google Scholar using relevant keywords for each health outcome, complemented by manual search of article reference lists and the expertise of relevant practitioners for each area studied. Results: The available literature suggest the effects of increased water intake on health may be direct, due to increased urine flow or urine dilution, or indirect, mediated by a reduction in osmotically -stimulated vasopressin (AVP). Urine flow affects the formation of kidney stones and recurrence of urinary tract infection, while increased circulating AVP is implicated in metabolic disease, chronic kidney disease, and autosomal dominant polycystic kidney disease. Conclusion: In order to ensure optimal hydration, it is proposed that optimal total water intake should approach 2.5 to 3.5 L day−1 to allow for the daily excretion of 2 to 3 L of dilute (< 500 mOsm kg−1) urine. Simple urinary markers of hydration such as urine color or void frequency may be used to monitor and adjust intake.
AB - Purpose: An increasing body of evidence suggests that excreting a generous volume of diluted urine is associated with short- and long-term beneficial health effects, especially for kidney and metabolic function. However, water intake and hydration remain under-investigated and optimal hydration is poorly and inconsistently defined. This review tests the hypothesis that optimal chronic water intake positively impacts various aspects of health and proposes an evidence-based definition of optimal hydration. Methods: Search strategy included PubMed and Google Scholar using relevant keywords for each health outcome, complemented by manual search of article reference lists and the expertise of relevant practitioners for each area studied. Results: The available literature suggest the effects of increased water intake on health may be direct, due to increased urine flow or urine dilution, or indirect, mediated by a reduction in osmotically -stimulated vasopressin (AVP). Urine flow affects the formation of kidney stones and recurrence of urinary tract infection, while increased circulating AVP is implicated in metabolic disease, chronic kidney disease, and autosomal dominant polycystic kidney disease. Conclusion: In order to ensure optimal hydration, it is proposed that optimal total water intake should approach 2.5 to 3.5 L day−1 to allow for the daily excretion of 2 to 3 L of dilute (< 500 mOsm kg−1) urine. Simple urinary markers of hydration such as urine color or void frequency may be used to monitor and adjust intake.
KW - Arginine vasopressin
KW - Copeptin
KW - Metabolic
KW - Renal
KW - Water
U2 - 10.1007/s00394-020-02296-z
DO - 10.1007/s00394-020-02296-z
M3 - Review article
C2 - 32632658
AN - SCOPUS:85087569799
VL - 60
SP - 1167
EP - 1180
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6215
IS - 3
ER -