@inproceedings{975dea2a010c402686eac731f7ddb8ab,
title = "Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer",
abstract = "We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.",
keywords = "diffuse reflectance, fibre probe, fluorescence, fluorescence lifetime, osteoarthritis, skin cancer, spectrometer",
author = "Alex Thompson and Hugh Manning and Mikkel Brydegaard and Sergio Coda and Gordon Kennedy and Rakesh Patalay and Ulrika Waitong-Braemming and {De Beule}, Pieter and Mark Neil and Stefan Andersson-Engels and Yoshifumi Itoh and Niels Bends{\o}e and Christopher Dunsby and Katarina Svanberg and French, {Paul M.}",
year = "2011",
doi = "10.1117/12.875120",
language = "English",
isbn = "9780819484321",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Biopsy IX",
note = "Optical Biopsy IX ; Conference date: 24-01-2011 Through 26-01-2011",
}
