Hypoxia and hypoxia-inducible factors in neuroblastoma

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26 Citations (SciVal)


Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2. Both HIF-1α and HIF-2α expression levels have been shown to correlate to patient outcome in various tumor forms and in neuroblastoma, a solid childhood tumor of the sympathetic nervous system, in particular, HIF-2α marks a subpopulation of immature neural crest-like perivascularly located cells and associates with aggressive disease and distant metastasis. It has for long been recognized that the HIF-α subunits are oxygen-dependently regulated at the post-translational level, via ubiquitination and proteasomal degradation. Evidence of oxygen-independent mechanisms of regulation, transcriptional control of EPAS1/HIF2A and possible cytoplasmic activities of HIF-2α has also emerged during recent years. In this review, we discuss these non-conventional actions of HIF-2α, its putative role as a therapeutic target and the constraints it carries, as well as the importance of HIF-2 activity in a vascularized setting, the so-called pseudo-hypoxic state.

Original languageEnglish
Pages (from-to)269-275
JournalCell and Tissue Research
Issue number2
Early online date2017 Oct 14
Publication statusPublished - 2018

Subject classification (UKÄ)

  • Cell and Molecular Biology
  • Cancer and Oncology


  • Cancer stem cell
  • Hypoxia
  • Hypoxia-inducible factor
  • Neuroblastoma
  • Vascularization


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