Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.

Marica Vaapil, Karolina Helczynska, René Villadsen, Ole W Petersen, Elisabet Johansson, Siv Beckman, Christer Larsson, Sven Påhlman, Annika Jögi

Research output: Contribution to journalArticlepeer-review

26 Citations (SciVal)
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Abstract

Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially have bearing on early stages of tumorigenesis.
Original languageEnglish
Article numbere46543
JournalPLoS ONE
Volume7
Issue number9
DOIs
Publication statusPublished - 2012

Subject classification (UKÄ)

  • Cancer and Oncology

Keywords

  • hypoxia
  • Breast cancer
  • differentiation
  • epithelial cells

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