Projects per year
Abstract
There is a large variability between individuals in the response to anesthetic drugs, that seriously limits the achievable performance of closed-loop controlled drug dosing. Full individualization of patient models based on early clinical response data has been suggested as a means to improve performance with maintained robustness (safety). We use estimation theoretic analysis and realization theory to characterize practical identifiability of the standard pharmacological model structure from anesthetic induction phase data and conclude that such approaches are not practically feasible.
| Original language | English |
|---|---|
| Pages (from-to) | 25-30 |
| Journal | IFAC-PapersOnLine |
| Volume | 54 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2021 |
| Event | 11th IFAC Symposium on Biological and Medical Systems - Ghent, Belgium Duration: 2021 Sept 19 → 2021 Sept 22 https://bms2021.ugent.be/scope.html |
Subject classification (UKÄ)
- Control Engineering
Free keywords
- Individualized anesthesia
- Identifiability
- Pharmacokinetic/ pharmacodynamic modeling
- Sensitivity analysis
- Drug delivery
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Dive into the research topics of 'Identifiability of pharmacological models for online individualization'. Together they form a unique fingerprint.Projects
- 2 Finished
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Hemodynamic Stabilization
Soltesz, K. (PI), Sjöberg, T. (Researcher), Paskevicius, A. (Researcher), Pigot, H. (Research student), Wahlquist, Y. (Researcher) & Sturk, C. (Researcher)
Swedish Government Agency for Innovation Systems (Vinnova), Swedish Research Council
2016/09/01 → 2023/12/31
Project: Research
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Anesthesia in Closed Loop
Soltesz, K. (PI), Troeng, O. (Research student), Bagge Carlson, F. (Research student) & Cervin, A. (Researcher)
2011/01/01 → 2020/01/01
Project: Research