Projects per year
There is a large variability between individuals in the response to anesthetic drugs, that seriously limits the achievable performance of closed-loop controlled drug dosing. Full individualization of patient models based on early clinical response data has been suggested as a means to improve performance with maintained robustness (safety). We use estimation theoretic analysis and realization theory to characterize practical identifiability of the standard pharmacological model structure from anesthetic induction phase data and conclude that such approaches are not practically feasible.
|Publication status||Published - 2021|
|Event||11th IFAC Symposium on Biological and Medical Systems - Ghent, Belgium|
Duration: 2021 Sep 19 → 2021 Sep 22
Subject classification (UKÄ)
- Control Engineering
- Individualized anesthesia
- Pharmacokinetic/ pharmacodynamic modeling
- Sensitivity analysis
- Drug delivery
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Soltesz, K., Sjöberg, T., Paskevicius, A., Pigot, H., Wahlquist, Y. & Sturk, C.
Swedish Government Agency for Innovation Systems (Vinnova), Swedish Research Council
2016/09/01 → 2023/12/31
Anesthesia in Closed Loop
Soltesz, K., Troeng, O., Bagge Carlson, F. & Cervin, A.
2011/01/01 → 2020/01/01