Identification and characterization of murine glycoprotein 2-expressing intestinal dendritic cells

Katarzyna M. Luda, Clement Da Silva, Fatemeh Ahmadi, Allan Mcl Mowat, Hiroshi Ohno, Knut Kotarsky, William W. Agace

Research output: Contribution to journalArticlepeer-review

Abstract

The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103+CD11b+ cDC in the murine small intestine (SI). GP2 expression was induced on CD103+CD11b+ cDC within the SI-LP and was regulated by IRF4, TGFβR1- and retinoic acid signalling. Mice selectively lacking Gp2 on CD103+CD11b+ cDC (huLang-Cre.gp2fl/fl mice) had normal numbers and proportions of innate and adaptive immune cells in the SI-LP suggesting that GP2 expression by CD103+CD11b+ cDC is not required for intestinal immune homoeostasis.

Original languageEnglish
Article numbere13219
Pages (from-to)1-12
JournalScandinavian Journal of Immunology
Volume96
Issue number5
DOIs
Publication statusPublished - 2022 Nov

Subject classification (UKÄ)

  • Immunology in the medical area

Free keywords

  • cDC2
  • dendritic cell
  • homeostasis
  • intestine
  • IRF4
  • retinoic acid
  • TGFβR1

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