Identification of a serum biomarker signature associated with metastatic prostate cancer

Venera Kuci Emruli, Leena Liljedahl, Ulrika Axelsson, Corinna Richter, Lisa Theorin, Anders Bjartell, Hans Lilja, Jenny Donovan, David Neal, Freddie C. Hamdy, Carl A.K. Borrebaeck

Research output: Contribution to journalArticlepeer-review


Purpose: Improved early diagnosis and determination of aggressiveness of prostate cancer (PC) is important to select suitable treatment options and to decrease over-treatment. The conventional marker is total prostate specific antigen (PSA) levels in blood, but lacks specificity and ability to accurately discriminate indolent from aggressive disease. Experimental design: In this study, we sought to identify a serum biomarker signature associated with metastatic PC. We measured 157 analytes in 363 serum samples from healthy subjects, patients with non-metastatic PC and patients with metastatic PC, using a recombinant antibody microarray. Results: A signature consisting of 69 proteins differentiating metastatic PC patients from healthy controls was identified. Conclusions and clinical relevance: The clinical value of this biomarker signature requires validation in larger independent patient cohorts before providing a new prospect for detection of metastatic PC.

Original languageEnglish
Article number2000025
JournalProteomics - Clinical Applications
Issue number2-3
Early online date2021
Publication statusPublished - 2021 May 1

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • affinity proteomics
  • antibody microarrays
  • biomarkers
  • cancer
  • prostate cancer


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