Identification of an HLA-DQ β-chain related genomic sequence associated with insulin-dependent diabetes

B. Michelsen, W. Kastern, A. Lernmark, D. Owerbach

Research output: Contribution to journalArticlepeer-review

Abstract

Restriction fragment length polymorphism detected by a cDNA probe for an HLA-DQ β-chain gene has revealed an HLA-DR4 linked BamH1 3.7 kb fragment which is rarely found among insulin-dependent diabetic patients. The present analysis demonstrates that the BamH1 3.7 kb fragment present on an HLA-DR4 positive chromosome in a healthy individual contains coding sequences for an HLA-DQ β-chain gene and that the absence of this fragment among HLA-DR4 positive insulin-dependent patients is due to the loss of a BamH1 restriction within an intervening sequence.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalBiomedica Biochimica Acta
Volume44
Issue number1
Publication statusPublished - 1985 Jan 1
Externally publishedYes

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