Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

Frida Pauly; Karin E Smedby; Mats Jerkeman; Henrik Hjalgrim; Mattias Ohlsson; Richard Rosenquist; Carl A K Borrebaeck; Christer Wingren

doi:10.1016/j.leukres.2014.03.010

Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

Frida Pauly, Karin E Smedby, Mats Jerkeman, Henrik Hjalgrim, Mattias Ohlsson, Richard Rosenquist, Carl A K Borrebaeck, Christer Wingren

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Abstract

B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.

Original language	English
Pages (from-to)	682-690
Journal	Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.leukres.2014.03.010
Publication status	Published - 2014

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2014.03.010

Elsevier__Pauly_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24754901?dopt=Abstract

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Pauly, F., Smedby, K. E., Jerkeman, M., Hjalgrim, H., Ohlsson, M., Rosenquist, R., Borrebaeck, C. A. K., & Wingren, C. (2014). Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays. Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis, 38(6), 682-690. https://doi.org/10.1016/j.leukres.2014.03.010

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title = "Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.",

abstract = "B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.",

author = "Frida Pauly and Smedby, {Karin E} and Mats Jerkeman and Henrik Hjalgrim and Mattias Ohlsson and Richard Rosenquist and Borrebaeck, {Carl A K} and Christer Wingren",

year = "2014",

doi = "10.1016/j.leukres.2014.03.010",

language = "English",

volume = "38",

pages = "682--690",

journal = "Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis",

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Pauly, F, Smedby, KE, Jerkeman, M, Hjalgrim, H, Ohlsson, M, Rosenquist, R, Borrebaeck, CAK & Wingren, C 2014, 'Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.', Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis, vol. 38, no. 6, pp. 682-690. https://doi.org/10.1016/j.leukres.2014.03.010

TY - JOUR

T1 - Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

AU - Pauly, Frida

AU - Smedby, Karin E

AU - Jerkeman, Mats

AU - Hjalgrim, Henrik

AU - Ohlsson, Mattias

AU - Rosenquist, Richard

AU - Borrebaeck, Carl A K

AU - Wingren, Christer

PY - 2014

Y1 - 2014

N2 - B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.

AB - B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.

U2 - 10.1016/j.leukres.2014.03.010

DO - 10.1016/j.leukres.2014.03.010

M3 - Article

C2 - 24754901

SN - 1873-5835

VL - 38

SP - 682

EP - 690

JO - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

JF - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

IS - 6

ER -

Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

Abstract

Subject classification (UKÄ)

UN SDGs

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