Identification of kidney tumor tissue by infrared spectroscopy of extracellular matrix

Vidita Urboniene, Milda Pucetaite, Feliksas Jankevicius, Arunas Zelvys, Valdas Sablinskas, Gerald Steiner

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11 Citations (SciVal)


Fourier transform infrared (FT-IR) spectroscopy was applied to characterize the extracellular matrix (ECM) of kidney tumor tissue and normal kidney tissue. Freshly resected tissue samples from 31 patients were pressed on a CaF2 substrate. FT-IR spectra obtained from ECM of tumor tissue exhibit stronger absorption bands in the spectral region from 1000 to 1200 cm−1 and around 1750 cm−1 than those obtained from normal tissue. It is likely that the spectra of ECM of kidney tumor tissue with large increases in the intensities of these
bands represent a higher concentration of fatty acids and glycerol. Amide I and amide II bands are stronger in the spectra of ECM from normal tissue, indicating a higher level of proteins. Our results suggest that FT-IR spectroscopy of the ECM is an innovative emerging technology for real-time intraoperative tumor diagnosis, which may improve margin clearance in renal cancer surgery.
Original languageEnglish
Article number087005
JournalJournal of Biomedical Optics
Issue number8
Publication statusPublished - 2014 Aug
Externally publishedYes


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