Identification of low-risk tumours in histological high-grade soft tissue sarcomas

Jacob Engellau, V. Samuelsson, Harald Anderson, B. Bjerkehagen, Pehr Rissler, K. Sundby-Hall, Anders Rydholm

Research output: Contribution to journalArticlepeer-review

25 Citations (SciVal)

Abstract

In more than one-third of patients with a histological high-grade malignant soft tissue sarcoma metastasis develops despite local control of the primary tumour. Hence, adjuvant chemotherapy is increasingly used for these relatively chemoresistant tumours which requires improved prognostication to exclude low-risk patients from overtreatment. We assessed the value of stepwise prognostication in a series of 434 histological high-grade STS of the extremity and trunk wall. Vascular invasion was used as the first discriminator whereafter the risk factors tumour necrosis, size (>8 cm) and infiltrating growth pattern were used to discriminate high- and low-risk tumours. We identified a high-risk group with a cumulative incidence of metastasis >0.4 at 5 years, and a low-risk group, comprising half of the tumours, with a cumulative incidence of metastasis <0.15. The model was validated in an independent material of 175 patients. This model improved prognostication in STS and is of value for identifying patients who probably should not receive adjuvant chemotherapy. (C) 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)1927-1934
JournalEuropean Journal of Cancer
Volume43
Issue number13
DOIs
Publication statusPublished - 2007

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Oncology, MV (013035000), Department of Orthopaedics (Lund) (013028000), Pathology, (Lund) (013030000), Cancer Epidemiology (013007100)

Subject classification (UKÄ)

  • Cancer and Oncology

Keywords

  • pattern
  • growth
  • vascular invasion
  • soft tissue sarcoma
  • prognostic factors
  • size
  • necrosis

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