IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

U. Westin; Eva Lundberg; Kjell Ohlsson

doi:10.1080/09629359891162

IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

U. Westin, Eva Lundberg, Kjell Ohlsson

Laryngoesophagology, Allergy and Life Quality

Skåne University Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

The secretory leukocyte protease inhibitor (SLPI) is a low-molecular- weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.

Original language	English
Pages (from-to)	217-220
Journal	Mediators of Inflammation
Volume	7
Issue number	3
DOIs	https://doi.org/10.1080/09629359891162
Publication status	Published - 1998

Subject classification (UKÄ)

Respiratory Medicine and Allergy

Free keywords

Chymase
Histamine
IgE
Nasal mucosa
SLPI

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10.1080/09629359891162

Cite this

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title = "IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release",

abstract = "The secretory leukocyte protease inhibitor (SLPI) is a low-molecular- weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.",

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AU - Westin, U.

AU - Lundberg, Eva

AU - Ohlsson, Kjell

PY - 1998

Y1 - 1998

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AB - The secretory leukocyte protease inhibitor (SLPI) is a low-molecular- weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.

KW - Chymase

KW - Histamine

KW - IgE

KW - Nasal mucosa

KW - SLPI

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SN - 0962-9351

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JO - Mediators of Inflammation

JF - Mediators of Inflammation

IS - 3

ER -

IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

Abstract

Subject classification (UKÄ)

Free keywords

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