IL-22 affects smooth muscle cell phenotype and plaque formation in apolipoprotein E knockout mice.

Sara Rattik, Karin Hultman, Uwe Rauch, Ingrid Söderberg, Lena Sundius, Irena Ljungcrantz, Anna Hultgårdh, Maria Wigren, Harry Björkbacka, Gunilla Nordin Fredrikson, Jan Nilsson

Research output: Contribution to journalArticlepeer-review

34 Citations (SciVal)
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Abstract

IL-22 is a recently discovered cytokine that belongs to the family of IL-10 related cytokines. It is produced by activated T-cells and innate lymphoid cells and has been suggested to be involved in tissue repair. As both inflammation and repair play important roles in atherosclerosis we investigated if IL-22 deficiency influences the disease process in Apoe(-/-) mice.
Original languageEnglish
Pages (from-to)506-514
JournalAtherosclerosis
Volume242
Issue number2
DOIs
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

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