Imaging diffusional variance by MRI [public]: The role of tensor-valued diffusion encoding and tissue heterogeneity

Research output: ThesisDoctoral Thesis (compilation)

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Diffusion MRI provides a non-invasive probe of tissue microstructure. We recently proposed a novel method for diffusion-weighted imaging, so-called q-space trajectory encoding, that facilitates tensor-valued diffusion encoding. This method grants access to b-tensors with multiple shapes and enables us to probe previously unexplored aspects of the tissue microstructure. Specifically, we can disentangle diffusional heterogeneity that originates from isotropic and anisotropic tissue structures; we call this diffusional variance decomposition (DIVIDE).
In Paper I, we investigated the statistical uncertainty of the total diffusional variance in the healthy brain. We found that the statistical power was heterogeneous between brain regions which needs to be taken into account when interpreting results.
In Paper II, we showed how spherical tensor encoding can be used to separate the total diffusional variance into its isotropic and anisotropic components. We also performed initial validation of the parameters in phantoms, and demonstrated that the imaging sequence could be implemented on a high-performance clinical MRI system.
In Paper III and V, we explored DIVIDE parameters in healthy brain tissue and tumor tissue. In healthy tissue, we found that diffusion anisotropy can be probed on the microscopic scale, and that metrics of anisotropy on the voxel scale are confounded by the orientation coherence of the microscopic structures. In meningioma and glioma tumors, we found a strong association between anisotropic variance and cell eccentricity, and between isotropic variance and variable cell density.
In Paper IV, we developed a method to optimize waveforms for tensor-valued diffusion encoding, and in Paper VI we demonstrated that whole-brain DIVIDE is technically feasible at most MRI systems in clinically feasible scan times.
Original languageEnglish
Awarding Institution
  • Medical Radiation Physics, Lund
  • Nilsson, Markus, Supervisor
  • Lätt, Jimmy, Supervisor
  • Ståhlberg, Freddy, Supervisor
Award date2016 Dec 2
Place of PublicationLund
ISBN (Print)978-91-7753-034-3
ISBN (electronic) 978-91-7753-035-0
Publication statusPublished - 2016 Nov

Bibliographical note

Defence details
Date: 2016-12-02
Time: 09:00
Place: Lecture hall 3 at Skåne University Hospital, Lund
External reviewer(s)
Name: Jones, Derek K.
Title: Professor
Affiliation: Cardiff University, United Kingdom

Subject classification (UKÄ)

  • Other Physics Topics
  • Cancer and Oncology
  • Radiology, Nuclear Medicine and Medical Imaging


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