TY - JOUR
T1 - Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin.
AU - Ekstrand, Matias
AU - Gustafsson Trajkovska, Maria
AU - Perman-Sundelin, Jeanna
AU - Fogelstrand, Per
AU - Adiels, Martin
AU - Johansson, Martin
AU - Mattsson-Hultén, Lillemor
AU - Borén, Jan
AU - Levin, Max
PY - 2015
Y1 - 2015
N2 - The first objective was to investigate if intracellular and extracellular levels of reactive oxygen species (ROS) within the mouse aorta increase before or after diet-induced lesion formation. The second objective was to investigate if intracellular and extracellular ROS correlates to cell composition in atherosclerotic lesions. The third objective was to investigate if intracellular and extracellular ROS levels within established atherosclerotic lesions can be reduced by lipid lowering by diet or atorvastatin.
AB - The first objective was to investigate if intracellular and extracellular levels of reactive oxygen species (ROS) within the mouse aorta increase before or after diet-induced lesion formation. The second objective was to investigate if intracellular and extracellular ROS correlates to cell composition in atherosclerotic lesions. The third objective was to investigate if intracellular and extracellular ROS levels within established atherosclerotic lesions can be reduced by lipid lowering by diet or atorvastatin.
U2 - 10.1371/journal.pone.0130898
DO - 10.1371/journal.pone.0130898
M3 - Article
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e0130898
ER -