Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin.

Matias Ekstrand, Maria Gustafsson Trajkovska, Jeanna Perman-Sundelin, Per Fogelstrand, Martin Adiels, Martin Johansson, Lillemor Mattsson-Hultén, Jan Borén, Max Levin

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Abstract

The first objective was to investigate if intracellular and extracellular levels of reactive oxygen species (ROS) within the mouse aorta increase before or after diet-induced lesion formation. The second objective was to investigate if intracellular and extracellular ROS correlates to cell composition in atherosclerotic lesions. The third objective was to investigate if intracellular and extracellular ROS levels within established atherosclerotic lesions can be reduced by lipid lowering by diet or atorvastatin.
Original languageEnglish
Article numbere0130898
JournalPLoS ONE
Volume10
Issue number6
DOIs
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

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