Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

Matilda Ahl; Marie K Taylor; Una Avdic; Anna Lundin; My Andersson; Åsa Amandusson; Eva Kumlien; Maria Compagno Strandberg; Christine T Ekdahl

doi:10.1016/j.heliyon.2023.e13938

Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

Matilda Ahl, Marie K Taylor, Una Avdic, Anna Lundin, My Andersson, Åsa Amandusson, Eva Kumlien, Maria Compagno Strandberg, Christine T Ekdahl

Research output: Contribution to journal › Article › peer-review

Abstract

Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling independent of co-morbidities.

Original language	English
Article number	e13938
Journal	Heliyon
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/j.heliyon.2023.e13938
Publication status	Published - 2023 Mar

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Neurology

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10.1016/j.heliyon.2023.e13938Licence: CC BY

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@article{b7f8d08b2ad54637afbb3ae178e13500,

title = "Immune response in blood before and after epileptic and psychogenic non-epileptic seizures",

abstract = " Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling independent of co-morbidities. ",

author = "Matilda Ahl and Taylor, {Marie K} and Una Avdic and Anna Lundin and My Andersson and {\AA}sa Amandusson and Eva Kumlien and {Compagno Strandberg}, Maria and Ekdahl, {Christine T}",

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year = "2023",

month = mar,

doi = "10.1016/j.heliyon.2023.e13938",

language = "English",

volume = "9",

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T1 - Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

AU - Ahl, Matilda

AU - Taylor, Marie K

AU - Avdic, Una

AU - Lundin, Anna

AU - Andersson, My

AU - Amandusson, Åsa

AU - Kumlien, Eva

AU - Compagno Strandberg, Maria

AU - Ekdahl, Christine T

PY - 2023/3

Y1 - 2023/3

N2 - Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling independent of co-morbidities.

AB - Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling independent of co-morbidities.

U2 - 10.1016/j.heliyon.2023.e13938

DO - 10.1016/j.heliyon.2023.e13938

M3 - Article

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SN - 2405-8440

VL - 9

JO - Heliyon

JF - Heliyon

IS - 3

M1 - e13938

ER -

Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

Abstract

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