Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils

Kang Chen; Weifeng Xu; Melanie Wilson; Bing He; Norman W. Miller; Eva Bengten; Eva-Stina Edholm; Paul A. Santini; Poonam Rath; April Chiu; Marco Cattalini; Jiri Litzman; James B. Bussel; Bihui Huang; Antonella Meini; Kristian Riesbeck; Charlotte Cunningham-Rundles; Alessandro Plebani; Andrea Cerutti

doi:10.1038/ni.1748

Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils

Kang Chen, Weifeng Xu, Melanie Wilson, Bing He, Norman W. Miller, Eva Bengten, Eva-Stina Edholm, Paul A. Santini, Poonam Rath, April Chiu, Marco Cattalini, Jiri Litzman, James B. Bussel, Bihui Huang, Antonella Meini, Kristian Riesbeck, Charlotte Cunningham-Rundles, Alessandro Plebani, Andrea Cerutti

Clinical Microbiology, Malmö

Research output: Contribution to journal › Article › peer-review

Abstract

Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.

Original language	English
Pages (from-to)	889-U121
Journal	Nature Immunology
Volume	10
Issue number	8
DOIs	https://doi.org/10.1038/ni.1748
Publication status	Published - 2009

Subject classification (UKÄ)

Microbiology in the medical area

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Chen, K., Xu, W., Wilson, M., He, B., Miller, N. W., Bengten, E., Edholm, E.-S., Santini, P. A., Rath, P., Chiu, A., Cattalini, M., Litzman, J., Bussel, J. B., Huang, B., Meini, A., Riesbeck, K., Cunningham-Rundles, C., Plebani, A., & Cerutti, A. (2009). Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nature Immunology, 10(8), 889-U121. https://doi.org/10.1038/ni.1748

@article{9827d5559fe04af3aba4f0b42718d772,

title = "Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils",

abstract = "Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.",

author = "Kang Chen and Weifeng Xu and Melanie Wilson and Bing He and Miller, {Norman W.} and Eva Bengten and Eva-Stina Edholm and Santini, {Paul A.} and Poonam Rath and April Chiu and Marco Cattalini and Jiri Litzman and Bussel, {James B.} and Bihui Huang and Antonella Meini and Kristian Riesbeck and Charlotte Cunningham-Rundles and Alessandro Plebani and Andrea Cerutti",

year = "2009",

doi = "10.1038/ni.1748",

language = "English",

volume = "10",

pages = "889--U121",

journal = "Nature Immunology",

issn = "1529-2908",

publisher = "Nature Publishing Group",

number = "8",

}

Chen, K, Xu, W, Wilson, M, He, B, Miller, NW, Bengten, E, Edholm, E-S, Santini, PA, Rath, P, Chiu, A, Cattalini, M, Litzman, J, Bussel, JB, Huang, B, Meini, A, Riesbeck, K, Cunningham-Rundles, C, Plebani, A & Cerutti, A 2009, 'Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils', Nature Immunology, vol. 10, no. 8, pp. 889-U121. https://doi.org/10.1038/ni.1748

TY - JOUR

T1 - Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils

AU - Chen, Kang

AU - Xu, Weifeng

AU - Wilson, Melanie

AU - He, Bing

AU - Miller, Norman W.

AU - Bengten, Eva

AU - Edholm, Eva-Stina

AU - Santini, Paul A.

AU - Rath, Poonam

AU - Chiu, April

AU - Cattalini, Marco

AU - Litzman, Jiri

AU - Bussel, James B.

AU - Huang, Bihui

AU - Meini, Antonella

AU - Riesbeck, Kristian

AU - Cunningham-Rundles, Charlotte

AU - Plebani, Alessandro

AU - Cerutti, Andrea

PY - 2009

Y1 - 2009

N2 - Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.

AB - Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.

U2 - 10.1038/ni.1748

DO - 10.1038/ni.1748

M3 - Article

C2 - 19561614

SN - 1529-2908

VL - 10

SP - 889-U121

JO - Nature Immunology

JF - Nature Immunology

IS - 8

ER -

Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils

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