Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.

Marie Fridberg; Sofia Kjellström; Lola Anagnostaki; Ingela Skogvall; Tomas Mustelin; Thomas Wiebe; Jenny L Persson; Michael Dictor; Anette Gjörloff Wingren

doi:10.1080/08880010802237054

Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.

Marie Fridberg, Sofia Kjellström, Lola Anagnostaki, Ingela Skogvall, Tomas Mustelin, Thomas Wiebe, Jenny L Persson, Michael Dictor, Anette Gjörloff Wingren

Research output: Contribution to journal › Article › peer-review

Abstract

Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.

Original language	English
Pages (from-to)	528-540
Journal	Pediatric Hematology & Oncology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1080/08880010802237054
Publication status	Published - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000), Tumour Biology, Malmö (013031300), Division V (013230900), Experimental cancer research (013017560)

Department affilation moved from v1000588 (Tumour Biology, Malmö) to v1000562 (Department of Translational Medicine) on 2016-01-18 14:39:25.

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/08880010802237054

http://www.ncbi.nlm.nih.gov/pubmed/18728972?dopt=Abstract

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1 Doctoral Thesis (compilation)

Protein kinases and phosphatases in B-cell lymphoma
Fridberg, M., 2009, Inst för Laboratoriemedicin, Avd för tumörbiologi, Malmö Universitetssjukhus, Lunds Universitet. 102 p.
Research output: Thesis › Doctoral Thesis (compilation)

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Fridberg, M., Kjellström, S., Anagnostaki, L., Skogvall, I., Mustelin, T., Wiebe, T., Persson, J. L., Dictor, M., & Gjörloff Wingren, A. (2008). Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls. Pediatric Hematology & Oncology, 25(6), 528-540. https://doi.org/10.1080/08880010802237054

@article{389f122cdeb44f43a8f48909a2eeadfc,

title = "Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.",

abstract = "Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.",

author = "Marie Fridberg and Sofia Kjellstr{\"o}m and Lola Anagnostaki and Ingela Skogvall and Tomas Mustelin and Thomas Wiebe and Persson, \{Jenny L\} and Michael Dictor and \{Gj{\"o}rloff Wingren\}, Anette",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Tumour Biology, Malm{\"o} (013031300), Division V (013230900), Experimental cancer research (013017560) Department affilation moved from v1000588 (Tumour Biology, Malm{\"o}) to v1000562 (Department of Translational Medicine) on 2016-01-18 14:39:25.",

year = "2008",

doi = "10.1080/08880010802237054",

language = "English",

volume = "25",

pages = "528--540",

journal = "Pediatric Hematology \& Oncology",

issn = "1521-0669",

publisher = "Hemisphere Pub. Corp.",

number = "6",

}

Fridberg, M, Kjellström, S, Anagnostaki, L, Skogvall, I, Mustelin, T, Wiebe, T, Persson, JL, Dictor, M & Gjörloff Wingren, A 2008, 'Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.', Pediatric Hematology & Oncology, vol. 25, no. 6, pp. 528-540. https://doi.org/10.1080/08880010802237054

Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls. / Fridberg, Marie; Kjellström, Sofia; Anagnostaki, Lola et al.
In: Pediatric Hematology & Oncology, Vol. 25, No. 6, 2008, p. 528-540.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.

AU - Fridberg, Marie

AU - Kjellström, Sofia

AU - Anagnostaki, Lola

AU - Skogvall, Ingela

AU - Mustelin, Tomas

AU - Wiebe, Thomas

AU - Persson, Jenny L

AU - Dictor, Michael

AU - Gjörloff Wingren, Anette

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Tumour Biology, Malmö (013031300), Division V (013230900), Experimental cancer research (013017560) Department affilation moved from v1000588 (Tumour Biology, Malmö) to v1000562 (Department of Translational Medicine) on 2016-01-18 14:39:25.

PY - 2008

Y1 - 2008

N2 - Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.

AB - Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.

UR - https://www.scopus.com/pages/publications/50249142447

U2 - 10.1080/08880010802237054

DO - 10.1080/08880010802237054

M3 - Article

C2 - 18728972

SN - 1521-0669

VL - 25

SP - 528

EP - 540

JO - Pediatric Hematology & Oncology

JF - Pediatric Hematology & Oncology

IS - 6

ER -

Fridberg M, Kjellström S, Anagnostaki L, Skogvall I, Mustelin T, Wiebe T et al. Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls. Pediatric Hematology & Oncology. 2008;25(6):528-540. doi: 10.1080/08880010802237054

Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.

Abstract

Bibliographical note

Subject classification (UKÄ)

UN SDGs

Access to Document

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Fingerprint

Research output

Protein kinases and phosphatases in B-cell lymphoma

Cite this