Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.

Jesper Kjaergaard; Niklas Nielsen; Matilde Winther-Jensen; Michael Wanscher; Tommaso Pellis; Ichael Kuiper; Jakob Hartvig Thomsen; Jørn Wetterslev; Tobias Cronberg; John Bro-Jeppesen; David Erlinge; Hans Friberg; Helle Søholm; Yvan Gasche; Janneke Horn; Jan Hovdenes; Pascal Stammet; Matthew P Wise; Anders Åneman; Christian Hassager

doi:10.1016/j.resuscitation.2015.06.021

Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.

Jesper Kjaergaard, Niklas Nielsen, Matilde Winther-Jensen, Michael Wanscher, Tommaso Pellis, Ichael Kuiper, Jakob Hartvig Thomsen, Jørn Wetterslev, Tobias Cronberg, John Bro-Jeppesen, David Erlinge, Hans Friberg, Helle Søholm, Yvan Gasche, Janneke Horn, Jan Hovdenes, Pascal Stammet, Matthew P Wise, Anders Åneman, Christian Hassager

Research output: Contribution to journal › Article › peer-review

Abstract

Time to Return of Spontaneous Circulation (ROSC) has a plausible relation to severity of hypoxic injury before and during resuscitation in Out-of-Hospital Cardiac Arrest (OHCA), and has consistently been associated with adverse outcome. The effect of Targeted Temperature Management (TTM) may not be similar over the full spectrum of time to ROSC. This study investigated the possible beneficial effect of targeting 33°C over 36°C on the prognostic importance of time to ROSC.

Original language	English
Pages (from-to)	310-316
Journal	Resuscitation
Volume	96
Issue number	Jul 7
DOIs	https://doi.org/10.1016/j.resuscitation.2015.06.021
Publication status	Published - 2015

Subject classification (UKÄ)

Anesthesiology and Intensive Care

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10.1016/j.resuscitation.2015.06.021

http://www.ncbi.nlm.nih.gov/pubmed/26159609?dopt=Abstract

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Kjaergaard, J., Nielsen, N., Winther-Jensen, M., Wanscher, M., Pellis, T., Kuiper, I., Hartvig Thomsen, J., Wetterslev, J., Cronberg, T., Bro-Jeppesen, J., Erlinge, D., Friberg, H., Søholm, H., Gasche, Y., Horn, J., Hovdenes, J., Stammet, P., Wise, M. P., Åneman, A., & Hassager, C. (2015). Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest. Resuscitation, 96(Jul 7), 310-316. https://doi.org/10.1016/j.resuscitation.2015.06.021

@article{a02daf34177c470a9101f6dafc0be0ec,

title = "Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.",

abstract = "Time to Return of Spontaneous Circulation (ROSC) has a plausible relation to severity of hypoxic injury before and during resuscitation in Out-of-Hospital Cardiac Arrest (OHCA), and has consistently been associated with adverse outcome. The effect of Targeted Temperature Management (TTM) may not be similar over the full spectrum of time to ROSC. This study investigated the possible beneficial effect of targeting 33°C over 36°C on the prognostic importance of time to ROSC.",

author = "Jesper Kjaergaard and Niklas Nielsen and Matilde Winther-Jensen and Michael Wanscher and Tommaso Pellis and Ichael Kuiper and {Hartvig Thomsen}, Jakob and J{\o}rn Wetterslev and Tobias Cronberg and John Bro-Jeppesen and David Erlinge and Hans Friberg and Helle S{\o}holm and Yvan Gasche and Janneke Horn and Jan Hovdenes and Pascal Stammet and Wise, {Matthew P} and Anders {\AA}neman and Christian Hassager",

year = "2015",

doi = "10.1016/j.resuscitation.2015.06.021",

language = "English",

volume = "96",

pages = "310--316",

journal = "Resuscitation",

issn = "1873-1570",

publisher = "Elsevier",

number = "Jul 7",

}

Kjaergaard, J, Nielsen, N, Winther-Jensen, M, Wanscher, M, Pellis, T, Kuiper, I, Hartvig Thomsen, J, Wetterslev, J, Cronberg, T, Bro-Jeppesen, J, Erlinge, D , Friberg, H, Søholm, H, Gasche, Y, Horn, J, Hovdenes, J, Stammet, P, Wise, MP, Åneman, A & Hassager, C 2015, 'Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.', Resuscitation, vol. 96, no. Jul 7, pp. 310-316. https://doi.org/10.1016/j.resuscitation.2015.06.021

Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest. / Kjaergaard, Jesper; Nielsen, Niklas; Winther-Jensen, Matilde et al.
In: Resuscitation, Vol. 96, No. Jul 7, 2015, p. 310-316.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.

AU - Kjaergaard, Jesper

AU - Nielsen, Niklas

AU - Winther-Jensen, Matilde

AU - Wanscher, Michael

AU - Pellis, Tommaso

AU - Kuiper, Ichael

AU - Hartvig Thomsen, Jakob

AU - Wetterslev, Jørn

AU - Cronberg, Tobias

AU - Bro-Jeppesen, John

AU - Erlinge, David

AU - Friberg, Hans

AU - Søholm, Helle

AU - Gasche, Yvan

AU - Horn, Janneke

AU - Hovdenes, Jan

AU - Stammet, Pascal

AU - Wise, Matthew P

AU - Åneman, Anders

AU - Hassager, Christian

PY - 2015

Y1 - 2015

N2 - Time to Return of Spontaneous Circulation (ROSC) has a plausible relation to severity of hypoxic injury before and during resuscitation in Out-of-Hospital Cardiac Arrest (OHCA), and has consistently been associated with adverse outcome. The effect of Targeted Temperature Management (TTM) may not be similar over the full spectrum of time to ROSC. This study investigated the possible beneficial effect of targeting 33°C over 36°C on the prognostic importance of time to ROSC.

AB - Time to Return of Spontaneous Circulation (ROSC) has a plausible relation to severity of hypoxic injury before and during resuscitation in Out-of-Hospital Cardiac Arrest (OHCA), and has consistently been associated with adverse outcome. The effect of Targeted Temperature Management (TTM) may not be similar over the full spectrum of time to ROSC. This study investigated the possible beneficial effect of targeting 33°C over 36°C on the prognostic importance of time to ROSC.

U2 - 10.1016/j.resuscitation.2015.06.021

DO - 10.1016/j.resuscitation.2015.06.021

M3 - Article

C2 - 26159609

SN - 1873-1570

VL - 96

SP - 310

EP - 316

JO - Resuscitation

JF - Resuscitation

IS - Jul 7

ER -

Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.

Abstract

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