Implications of stress-induced gene expression for hematopoietic stem cell aging studies

Anna Konturek-Ciesla; Rasmus Olofzon; Shabnam Kharazi; David Bryder

doi:10.1038/s43587-023-00558-z

Implications of stress-induced gene expression for hematopoietic stem cell aging studies

Anna Konturek-Ciesla, Rasmus Olofzon, Shabnam Kharazi, David Bryder

Research output: Contribution to journal › Article › peer-review

Abstract

A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.

Original language	English
Pages (from-to)	177–184
Number of pages	8
Journal	Nature Aging
Volume	4
Issue number	2
Early online date	2024
DOIs	https://doi.org/10.1038/s43587-023-00558-z
Publication status	Published - 2024

Subject classification (UKÄ)

Cell and Molecular Biology

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10.1038/s43587-023-00558-zLicence: CC BY

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title = "Implications of stress-induced gene expression for hematopoietic stem cell aging studies",

abstract = "A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.",

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AU - Kharazi, Shabnam

AU - Bryder, David

PY - 2024

Y1 - 2024

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AB - A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.

U2 - 10.1038/s43587-023-00558-z

DO - 10.1038/s43587-023-00558-z

M3 - Article

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SP - 177

EP - 184

JO - Nature Aging

JF - Nature Aging

IS - 2

ER -

Implications of stress-induced gene expression for hematopoietic stem cell aging studies

Abstract

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