Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes

A. Lenshof; Cecilia Magnusson; P. Augustsson; B. Haflidadottir; H. Lilja; T. Laurell

Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes

A. Lenshof, Cecilia Magnusson, P. Augustsson, B. Haflidadottir, H. Lilja, T. Laurell

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The improved flow control enables recovery of rare tumor cell populations ≈10 cells/mL spiked in whole blood at a recovery close to 100%.

Original language	English
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	594-596
ISBN (Electronic)	9780979806476
Publication status	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 2014 Oct 26 → 2014 Oct 30 Conference number: 18

Publication series

Name	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	2014/10/26 → 2014/10/30

Bibliographical note

Publisher Copyright:
© 14CBMS.

Subject classification (UKÄ)

Medical Biotechnology

Free keywords

Acoustophoresis
Cancer
Circulation tumor cells
Rare cell
Separation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Lenshof, A., Magnusson, C., Augustsson, P., Haflidadottir, B., Lilja, H., & Laurell, T. (2014). Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 594-596). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.

Lenshof, A. ; Magnusson, Cecilia ; Augustsson, P. et al. / Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 594-596 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

@inproceedings{075085983cb84425a1d3a03ecb775584,

title = "Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes",

abstract = "We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The improved flow control enables recovery of rare tumor cell populations ≈10 cells/mL spiked in whole blood at a recovery close to 100\%.",

keywords = "Acoustophoresis, Cancer, Circulation tumor cells, Rare cell, Separation",

author = "A. Lenshof and Cecilia Magnusson and P. Augustsson and B. Haflidadottir and H. Lilja and T. Laurell",

note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

year = "2014",

language = "English",

series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

pages = "594--596",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

}

Lenshof, A , Magnusson, C , Augustsson, P, Haflidadottir, B, Lilja, H & Laurell, T 2014, Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, pp. 594-596, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 2014/10/26.

Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes. / Lenshof, A.; Magnusson, Cecilia ; Augustsson, P. et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 594-596 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

TY - GEN

T1 - Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes

AU - Lenshof, A.

AU - Magnusson, Cecilia

AU - Augustsson, P.

AU - Haflidadottir, B.

AU - Lilja, H.

AU - Laurell, T.

N1 - Conference code: 18

PY - 2014

Y1 - 2014

N2 - We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The improved flow control enables recovery of rare tumor cell populations ≈10 cells/mL spiked in whole blood at a recovery close to 100%.

AB - We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The improved flow control enables recovery of rare tumor cell populations ≈10 cells/mL spiked in whole blood at a recovery close to 100%.

KW - Acoustophoresis

KW - Cancer

KW - Circulation tumor cells

KW - Rare cell

KW - Separation

UR - https://www.scopus.com/pages/publications/84941687206

UR - https://www.proceedings.com/content/024/024717webtoc.pdf

M3 - Paper in conference proceeding

AN - SCOPUS:84941687206

T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

SP - 594

EP - 596

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Lenshof A , Magnusson C , Augustsson P, Haflidadottir B, Lilja H , Laurell T. Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 594-596. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes

Abstract

Publication series

Conference

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

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Cite this