In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state

Martin W. Krueger, Andreas Dorn, David U. J. Keller, Fredrik Holmqvist, Jonas Carlson, Pyotr Platonov, Kawal S. Rhode, Reza Razavi, Gunnar Seemann, Olaf Doessel

Research output: Contribution to journalArticlepeer-review


Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the total number of AF patients is constantly increasing. The mechanisms leading to and sustaining AF are not completely understood yet. Heterogeneities in atrial electrophysiology seem to play an important role in this context. Although some heterogeneities have been used in in-silico human atrial modeling studies, they have not been thoroughly investigated. In this study, the original electrophysiological (EP) models of Courtemanche et al., Nygren et al. and Maleckar et al. were adjusted to reproduce action potentials in 13 atrial regions. The parameter sets were validated against experimental action potential duration data and ECG data from patients with AV block. The use of the heterogeneous EP model led to a more synchronized repolarization sequence in a variety of 3D atrial anatomical models. Combination of the heterogeneous EP model with a model of persistent AF-remodeled electrophysiology led to a drastic change in cell electrophysiology. Simulated Ta-waves were significantly shorter under the remodeling. The heterogeneities in cell electrophysiology explain the previously observed Ta-wave effects. The results mark an important step toward the reliable simulation of the atrial repolarization sequence, give a deeper understanding of the mechanism of atrial repolarization and enable further clinical investigations.
Original languageEnglish
Pages (from-to)1105-1119
JournalMedical & Biological Engineering & Computing
Issue number10
Publication statusPublished - 2013

Subject classification (UKÄ)

  • Other Medical Engineering

Free keywords

  • Atrial repolarization
  • Cardiac electrophysiology
  • Multi-scale cardiac
  • modeling
  • Atrial fibrillation
  • Electrical remodeling


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