In vitro effect of fibrinogen on Candida albicans germ tube formation

A Rodrigues, C P Vaz, Per-Anders Mårdh, A F da Fonseca, J M de Oliveira

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4 Citations (Scopus)


Pseudohyphae formation by Candida albicans blastoconidia, as seen in vaginal smears, is a phenotypical change commonly assumed to mean fungal invasiveness, i.e. not mere colonization. C. albicans forms germ tubes in vitro in the presence of serum. In our search for inhibitory components of germ tube formation, we decided to study fibrinogen. The inhibition of germ tube formation by clinical isolates of C. albicans was evaluated in the presence of serial concentrations of fraction I, type IV and fraction I, type Is of fibrinogen from bovine plasma. Fibrinogen showed a dose-dependent, pH-independent inhibitory effect on the germ tube formation by C. albicans.
Original languageEnglish
Pages (from-to)1020-1022
Journal APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Issue number11
Publication statusPublished - 1999

Subject classification (UKÄ)

  • Obstetrics, Gynecology and Reproductive Medicine


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