Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry

Vladimir Lj Lazarevic; Aldana Rosso; Gunnar Juliusson; Petar Antunovic; Åsa Rangert Derolf; Stefan Deneberg; Lars Möllgård; Bertil Uggla; Lovisa Wennström; Anders Wahlin; Martin Höglund; Sören Lehmann; Bertil Johansson

doi:10.1111/ejh.12861

Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry

Vladimir Lj Lazarevic, Aldana Rosso, Gunnar Juliusson, Petar Antunovic, Åsa Rangert Derolf, Stefan Deneberg, Lars Möllgård, Bertil Uggla, Lovisa Wennström, Anders Wahlin, Martin Höglund, Sören Lehmann, Bertil Johansson

Research output: Contribution to journal › Article › peer-review

4 Citations (SciVal)

Abstract

OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.

RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P<.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 (P=.013).

CONCLUSION: AML with single trisomies, with the exception of +13, should be grouped as IR.

Original language	English
Pages (from-to)	493-500
Journal	European Journal of Haematology
Volume	98
Issue number	5
Early online date	2017 Feb 2
DOIs	https://doi.org/10.1111/ejh.12861
Publication status	Published - 2017

Subject classification (UKÄ)

Hematology

Keywords

Journal Article

Access to Document

10.1111/ejh.12861

Cite this

Lj Lazarevic, V., Rosso, A., Juliusson, G., Antunovic, P., Derolf, Å. R., Deneberg, S., Möllgård, L., Uggla, B., Wennström, L., Wahlin, A., Höglund, M., Lehmann, S., & Johansson, B. (2017). Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry. European Journal of Haematology, 98(5), 493-500. https://doi.org/10.1111/ejh.12861

Lj Lazarevic, Vladimir ; Rosso, Aldana ; Juliusson, Gunnar ; Antunovic, Petar ; Derolf, Åsa Rangert ; Deneberg, Stefan ; Möllgård, Lars ; Uggla, Bertil ; Wennström, Lovisa ; Wahlin, Anders ; Höglund, Martin ; Lehmann, Sören ; Johansson, Bertil. / Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia : A population-based study from the Swedish AML registry. In: European Journal of Haematology. 2017 ; Vol. 98, No. 5. pp. 493-500.

@article{fb73da165cf8417b9b9d473773f33563,

title = "Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry",

abstract = "OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P<.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 (P=.013).CONCLUSION: AML with single trisomies, with the exception of +13, should be grouped as IR.",

keywords = "Journal Article",

author = "{Lj Lazarevic}, Vladimir and Aldana Rosso and Gunnar Juliusson and Petar Antunovic and Derolf, {{\AA}sa Rangert} and Stefan Deneberg and Lars M{\"o}llg{\aa}rd and Bertil Uggla and Lovisa Wennstr{\"o}m and Anders Wahlin and Martin H{\"o}glund and S{\"o}ren Lehmann and Bertil Johansson",

note = "{\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2017",

doi = "10.1111/ejh.12861",

language = "English",

volume = "98",

pages = "493--500",

journal = "European Journal of Haematology",

issn = "1600-0609",

publisher = "Wiley-Blackwell",

number = "5",

}

Lj Lazarevic, V , Rosso, A , Juliusson, G, Antunovic, P, Derolf, ÅR, Deneberg, S, Möllgård, L, Uggla, B, Wennström, L, Wahlin, A, Höglund, M, Lehmann, S & Johansson, B 2017, 'Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry', European Journal of Haematology, vol. 98, no. 5, pp. 493-500. https://doi.org/10.1111/ejh.12861

Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia : A population-based study from the Swedish AML registry. / Lj Lazarevic, Vladimir ; Rosso, Aldana ; Juliusson, Gunnar; Antunovic, Petar; Derolf, Åsa Rangert; Deneberg, Stefan; Möllgård, Lars; Uggla, Bertil; Wennström, Lovisa; Wahlin, Anders; Höglund, Martin; Lehmann, Sören; Johansson, Bertil.

In: European Journal of Haematology, Vol. 98, No. 5, 2017, p. 493-500.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia

T2 - A population-based study from the Swedish AML registry

AU - Lj Lazarevic, Vladimir

AU - Rosso, Aldana

AU - Juliusson, Gunnar

AU - Antunovic, Petar

AU - Derolf, Åsa Rangert

AU - Deneberg, Stefan

AU - Möllgård, Lars

AU - Uggla, Bertil

AU - Wennström, Lovisa

AU - Wahlin, Anders

AU - Höglund, Martin

AU - Lehmann, Sören

AU - Johansson, Bertil

PY - 2017

Y1 - 2017

N2 - OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P<.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 (P=.013).CONCLUSION: AML with single trisomies, with the exception of +13, should be grouped as IR.

AB - OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P<.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 (P=.013).CONCLUSION: AML with single trisomies, with the exception of +13, should be grouped as IR.

KW - Journal Article

U2 - 10.1111/ejh.12861

DO - 10.1111/ejh.12861

M3 - Article

C2 - 28152233

VL - 98

SP - 493

EP - 500

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 1600-0609

IS - 5

ER -

Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry

Abstract

Subject classification (UKÄ)

Keywords

Access to Document

Fingerprint

Cite this