TY - JOUR
T1 - Incidence of and risk factors for neonatal morbidity after active perinatal care: extremely preterm infants study in Sweden (EXPRESS)
AU - Austeng, Dordi
AU - Blennow, Mats
AU - Ewald, Uwe
AU - Fellman, Vineta
AU - Fritz, Thomas
AU - Hellstrom-Westas, Lena
AU - Hellstrom, Ann
AU - Holmgren, Per Ake
AU - Holmstrom, Gerd
AU - Jakobsson, Peter
AU - Jeppsson, Annika
AU - Johansson, Kent
AU - Källén, Karin
AU - Lagercrantz, Hugo
AU - Laurini, Ricardo
AU - Lindberg, Eva
AU - Lundqvist, Anita
AU - Marsal, Karel
AU - Nilstun, Tore
AU - Norden-Lindeberg, Solveig
AU - Norman, Mikael
AU - Olhager, Elisabeth
AU - Oestlund, Ingrid
AU - Serenius, Fredrik
AU - Simic, Marija
AU - Sjors, Gunnar
AU - Stigson, Lennart
AU - Stjernqvist, Karin
AU - Stromberg, Bo
AU - Tornqvist, Kristina
AU - Wennergren, Margareta
AU - Wallin, Agneta
AU - Westgren, Magnus
N1 - The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Obstetrics and Gynaecology (Lund) (013018000), Department of Medical Ethics (013230023), Division of Nursing (Closed 2012) (013065000), Reproductive Epidemiology/Tornblad Institute (013003000), Ophthalmology (Lund) (013043000), Department of Psychology (012010000), Paediatrics (Lund) (013002000)
PY - 2010
Y1 - 2010
N2 - Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
AB - Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
KW - Patent ductus arteriosus
KW - enterocolitis
KW - Necrotizing
KW - Bronchopulmonary dysplasia
KW - Intraventricular haemorrhage
KW - Retinopathy of prematurity
U2 - 10.1111/j.1651-2227.2010.01846.x
DO - 10.1111/j.1651-2227.2010.01846.x
M3 - Article
C2 - 20456261
SN - 1651-2227
VL - 99
SP - 978
EP - 992
JO - Acta Pædiatrica
JF - Acta Pædiatrica
IS - 7
ER -