Incidence of Primary Cancers and Intracranial Tumour Recurrences in Growth Hormone-Treated and Untreated Adult Hypopituitary Patients: Analyses from Hypopituitary Control and Complications Study

Christopher J Child; Daniel Conroy; Alan G Zimmermann; Whitney Woodmansee; Eva Marie Erfurth; Leslie Robison

doi:10.1530/EJE-14-1123

Incidence of Primary Cancers and Intracranial Tumour Recurrences in Growth Hormone-Treated and Untreated Adult Hypopituitary Patients: Analyses from Hypopituitary Control and Complications Study

Christopher J Child, Daniel Conroy, Alan G Zimmermann, Whitney Woodmansee, Eva Marie Erfurth, Leslie Robison

Medicine/Emergency Medicine, Lund

Research output: Contribution to journal › Article › peer-review

Abstract

Speculation remains that growth hormone (GH) treatment is associated with increased neoplasia risk. Studies in GH-treated childhood cancer survivors suggested higher rates of second neoplasms, while cancer risk data for GH-treated and untreated hypopituitary adults have been variable. We present primary cancer risk data from the Hypopituitary Control and Complications Study (HypoCCS) with a focus on specific cancers, and assessment of recurrence rates for pituitary adenoma (PA) and craniopharyngioma (CP).

Original language	English
Pages (from-to)	779-790
Journal	European Journal of Endocrinology
Volume	172
Issue number	6
DOIs	https://doi.org/10.1530/EJE-14-1123
Publication status	Published - 2015

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1530/EJE-14-1123

http://www.ncbi.nlm.nih.gov/pubmed/25810462?dopt=Abstract

Cite this

Child, C. J., Conroy, D., Zimmermann, A. G., Woodmansee, W., Erfurth, E. M., & Robison, L. (2015). Incidence of Primary Cancers and Intracranial Tumour Recurrences in Growth Hormone-Treated and Untreated Adult Hypopituitary Patients: Analyses from Hypopituitary Control and Complications Study. European Journal of Endocrinology, 172(6), 779-790. https://doi.org/10.1530/EJE-14-1123

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title = "Incidence of Primary Cancers and Intracranial Tumour Recurrences in Growth Hormone-Treated and Untreated Adult Hypopituitary Patients: Analyses from Hypopituitary Control and Complications Study",

abstract = "Speculation remains that growth hormone (GH) treatment is associated with increased neoplasia risk. Studies in GH-treated childhood cancer survivors suggested higher rates of second neoplasms, while cancer risk data for GH-treated and untreated hypopituitary adults have been variable. We present primary cancer risk data from the Hypopituitary Control and Complications Study (HypoCCS) with a focus on specific cancers, and assessment of recurrence rates for pituitary adenoma (PA) and craniopharyngioma (CP).",

author = "Child, {Christopher J} and Daniel Conroy and Zimmermann, {Alan G} and Whitney Woodmansee and Erfurth, {Eva Marie} and Leslie Robison",

year = "2015",

doi = "10.1530/EJE-14-1123",

language = "English",

volume = "172",

pages = "779--790",

journal = "European Journal of Endocrinology",

issn = "1479-683X",

publisher = "Society of the European Journal of Endocrinology",

number = "6",

}

Child, CJ, Conroy, D, Zimmermann, AG, Woodmansee, W, Erfurth, EM & Robison, L 2015, 'Incidence of Primary Cancers and Intracranial Tumour Recurrences in Growth Hormone-Treated and Untreated Adult Hypopituitary Patients: Analyses from Hypopituitary Control and Complications Study', European Journal of Endocrinology, vol. 172, no. 6, pp. 779-790. https://doi.org/10.1530/EJE-14-1123

Incidence of Primary Cancers and Intracranial Tumour Recurrences in Growth Hormone-Treated and Untreated Adult Hypopituitary Patients: Analyses from Hypopituitary Control and Complications Study. / Child, Christopher J; Conroy, Daniel; Zimmermann, Alan G et al.
In: European Journal of Endocrinology, Vol. 172, No. 6, 2015, p. 779-790.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Incidence of Primary Cancers and Intracranial Tumour Recurrences in Growth Hormone-Treated and Untreated Adult Hypopituitary Patients: Analyses from Hypopituitary Control and Complications Study

AU - Child, Christopher J

AU - Conroy, Daniel

AU - Zimmermann, Alan G

AU - Woodmansee, Whitney

AU - Erfurth, Eva Marie

AU - Robison, Leslie

PY - 2015

Y1 - 2015

N2 - Speculation remains that growth hormone (GH) treatment is associated with increased neoplasia risk. Studies in GH-treated childhood cancer survivors suggested higher rates of second neoplasms, while cancer risk data for GH-treated and untreated hypopituitary adults have been variable. We present primary cancer risk data from the Hypopituitary Control and Complications Study (HypoCCS) with a focus on specific cancers, and assessment of recurrence rates for pituitary adenoma (PA) and craniopharyngioma (CP).

AB - Speculation remains that growth hormone (GH) treatment is associated with increased neoplasia risk. Studies in GH-treated childhood cancer survivors suggested higher rates of second neoplasms, while cancer risk data for GH-treated and untreated hypopituitary adults have been variable. We present primary cancer risk data from the Hypopituitary Control and Complications Study (HypoCCS) with a focus on specific cancers, and assessment of recurrence rates for pituitary adenoma (PA) and craniopharyngioma (CP).

U2 - 10.1530/EJE-14-1123

DO - 10.1530/EJE-14-1123

M3 - Article

C2 - 25810462

SN - 1479-683X

VL - 172

SP - 779

EP - 790

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 6

ER -

Incidence of Primary Cancers and Intracranial Tumour Recurrences in Growth Hormone-Treated and Untreated Adult Hypopituitary Patients: Analyses from Hypopituitary Control and Complications Study

Abstract

Subject classification (UKÄ)

UN SDGs

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