Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Irma Mahmutovic Persson; Hamid Akbarshahi; Mandy Menzel; Angelica Brandelius; Lena Uller

doi:10.1186/s12967-016-0808-x

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Irma Mahmutovic Persson, Hamid Akbarshahi, Mandy Menzel, Angelica Brandelius, Lena Uller

Respiratory Immunopharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

Original language	English
Article number	52
Journal	Journal of Translational Medicine
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s12967-016-0808-x
Publication status	Published - 2016

Subject classification (UKÄ)

Respiratory Medicine and Allergy

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10.1186/s12967-016-0808-x

http://www.ncbi.nlm.nih.gov/pubmed/26879906?dopt=Abstract

1 Doctoral Thesis (compilation)

Translational studies of viral-induced asthma and COPD exacerbations
Mahmutovic Persson, I., 2016, Lund: Lund University: Faculty of Medicine. 122 p.
Research output: Thesis › Doctoral Thesis (compilation)

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AU - Brandelius, Angelica

AU - Uller, Lena

PY - 2016

Y1 - 2016

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AB - Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

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Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Abstract

Subject classification (UKÄ)

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Research output

Translational studies of viral-induced asthma and COPD exacerbations

Cite this