Increased metabolism in the R6/2 mouse model of Huntington's disease.

Jorien m van der Burg; Karl Bacos; Nigel I Wood; Andreas Lindqvist; Nils Wierup; Ben Woodman; Jaclyn Wamsteeker; Ruben Smith; Tomas Deierborg; Michael J Kuhar; Gillian P Bates; Hindrik Mulder; Charlotte Erlanson-Albertsson; Jennifer Morton; Patrik Brundin; Åsa Petersén; Maria Björkqvist

doi:10.1016/j.nbd.2007.07.029

Increased metabolism in the R6/2 mouse model of Huntington's disease.

Jorien m van der Burg, Karl Bacos, Nigel I Wood, Andreas Lindqvist, Nils Wierup, Ben Woodman, Jaclyn Wamsteeker, Ruben Smith, Tomas Deierborg, Michael J Kuhar, Gillian P Bates, Hindrik Mulder, Charlotte Erlanson-Albertsson, Jennifer Morton, Patrik Brundin, Åsa Petersén, Maria Björkqvist

Research output: Contribution to journal › Article › peer-review

Abstract

Huntington’s disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors.

Original language	English
Pages (from-to)	41-51
Journal	Neurobiology of Disease
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.nbd.2007.07.029
Publication status	Published - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Apetite Regulation (013212030), Molecular Metabolism (013212001), Neuronal Survival (013212041), Translational Neuroendocrinology (013210010), Neuroendocrine Cell Biology (013212008)

Subject classification (UKÄ)

Neurosciences

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10.1016/j.nbd.2007.07.029

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17920283&dopt=Abstract

1 Doctoral Thesis (compilation)

Beyond the basal ganglia
van der Burg, J. M., 2008, Institutionen för Experimentell Medicinsk Vetenskap, Lunds Universitet. 139 p.
Research output: Thesis › Doctoral Thesis (compilation)

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van der Burg, J. M., Bacos, K., Wood, N. I., Lindqvist, A., Wierup, N., Woodman, B., Wamsteeker, J., Smith, R., Deierborg, T., Kuhar, M. J., Bates, G. P., Mulder, H., Erlanson-Albertsson, C., Morton, J., Brundin, P., Petersén, Å., & Björkqvist, M. (2008). Increased metabolism in the R6/2 mouse model of Huntington's disease. Neurobiology of Disease, 29(1), 41-51. https://doi.org/10.1016/j.nbd.2007.07.029

@article{07e064346ba040929f136570de5756d3,

title = "Increased metabolism in the R6/2 mouse model of Huntington's disease.",

abstract = "Huntington{\textquoteright}s disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors.",

author = "{van der Burg}, {Jorien m} and Karl Bacos and Wood, {Nigel I} and Andreas Lindqvist and Nils Wierup and Ben Woodman and Jaclyn Wamsteeker and Ruben Smith and Tomas Deierborg and Kuhar, {Michael J} and Bates, {Gillian P} and Hindrik Mulder and Charlotte Erlanson-Albertsson and Jennifer Morton and Patrik Brundin and {\AA}sa Peters{\'e}n and Maria Bj{\"o}rkqvist",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Apetite Regulation (013212030), Molecular Metabolism (013212001), Neuronal Survival (013212041), Translational Neuroendocrinology (013210010), Neuroendocrine Cell Biology (013212008)",

year = "2008",

doi = "10.1016/j.nbd.2007.07.029",

language = "English",

volume = "29",

pages = "41--51",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Academic Press",

number = "1",

}

van der Burg, JM, Bacos, K, Wood, NI, Lindqvist, A , Wierup, N, Woodman, B, Wamsteeker, J, Smith, R , Deierborg, T, Kuhar, MJ, Bates, GP, Mulder, H , Erlanson-Albertsson, C, Morton, J, Brundin, P, Petersén, Å & Björkqvist, M 2008, 'Increased metabolism in the R6/2 mouse model of Huntington's disease.', Neurobiology of Disease, vol. 29, no. 1, pp. 41-51. https://doi.org/10.1016/j.nbd.2007.07.029

TY - JOUR

T1 - Increased metabolism in the R6/2 mouse model of Huntington's disease.

AU - van der Burg, Jorien m

AU - Bacos, Karl

AU - Wood, Nigel I

AU - Lindqvist, Andreas

AU - Wierup, Nils

AU - Woodman, Ben

AU - Wamsteeker, Jaclyn

AU - Smith, Ruben

AU - Deierborg, Tomas

AU - Kuhar, Michael J

AU - Bates, Gillian P

AU - Mulder, Hindrik

AU - Erlanson-Albertsson, Charlotte

AU - Morton, Jennifer

AU - Brundin, Patrik

AU - Petersén, Åsa

AU - Björkqvist, Maria

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Apetite Regulation (013212030), Molecular Metabolism (013212001), Neuronal Survival (013212041), Translational Neuroendocrinology (013210010), Neuroendocrine Cell Biology (013212008)

PY - 2008

Y1 - 2008

N2 - Huntington’s disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors.

AB - Huntington’s disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered and caloric intake was not decreased until 11 weeks of age, which led us to hypothesize that increased metabolism might underlie the weight loss. Indeed, oxygen consumption in R6/2 mice was elevated from 6 weeks of age, indicative of an increased metabolism. Several organ systems that regulate weight and metabolism, including the hypothalamus, the stomach and adipose tissue displayed abnormalities in R6/2 mice. Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors.

U2 - 10.1016/j.nbd.2007.07.029

DO - 10.1016/j.nbd.2007.07.029

M3 - Article

SN - 0969-9961

VL - 29

SP - 41

EP - 51

JO - Neurobiology of Disease

JF - Neurobiology of Disease

IS - 1

ER -

Increased metabolism in the R6/2 mouse model of Huntington's disease.

Abstract

Bibliographical note

Subject classification (UKÄ)

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Research output

Beyond the basal ganglia

Cite this