Increasing depth penetration in biological tissue imaging using 808-nm excited Nd3+/Yb3+/Er3+-doped upconverting nanoparticles

Hugo Soderlund, Monirehalsadat Mousavi, Haichun Liu, Stefan Andersson-Engels

Research output: Contribution to journalArticlepeer-review

Abstract

Ytterbium (Yb3+)-sensitized upconverting nanoparticles (UCNPs) are excited at 975 nm causing relatively high absorption in tissue. A new type of UCNPs with neodymium (Nd3+) and Yb3+ codoping is excitable at a 808-nm wavelength. At this wavelength, the tissue absorption is lower. Here we quantify, both experimentally and theoretically, to what extent Nd3+-doped UCNPs will provide an increased signal at larger depths in tissue compared to conventional 975-nm excited UCNPs. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
Original languageEnglish
Article number086008
JournalJournal of Biomedical Optics
Volume20
Issue number8
DOIs
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Biomedical Laboratory Science/Technology

Free keywords

  • upconverting nanoparticles
  • tissue optics
  • deep tissue imaging

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