@inproceedings{94549e79c66044058d88732edfd77693,
title = "Indentation testing of a bone defect filled with two different injectable bone substitutes",
abstract = "Injectable bone substitutes (IBS) based on calcium phosphate (CaP) and/or calcium sulphate (CaS) are used as fillers in bone defects to stimulate bone integration and allow mechanical loading. Two types of IBS, IBS-1 is CaP+20%CaS and IBS-2 is CaS+40% hydroxyapatite, were investigated. The materials were injected into holes in the femur and tibia in rabbits. After 10 weeks the femora were subjected to indentation testing and tibiae were prepared for histology evaluation. IBS-1 lead to a higher indentation load compared to control, that is no material inserted, while IBS-2 showed no significant difference between material and control. Histology showed that with IBS-1, the bone penetrated into and integrated with the material in the defect. With IBS-2, new bone grew into the outer 0.5-1.0 mm. The materials could be used for different indications, such as to support fracture healing or in contained cavities",
keywords = "CaPO<sub>4</sub>, cavities, fracture healing, histology evaluation, bone defect, indentation testing, injectable bone substitutes, calcium phosphate, calcium sulphate, bone integration, CaSO<sub>4</sub>, mechanical loading, hydroxyapatite, femur, rabbits, tibia",
author = "Jian-Sheng Wang and K Tanner and Saba Abdulghani and Lars Lidgren",
year = "2005",
doi = "10.4028/www.scientific.net/KEM.284-286.89",
language = "English",
volume = "284-286",
publisher = "Trans Tech Publications",
pages = "89--92",
booktitle = "Key Engineering Materials",
address = "Germany",
note = "17th International Symposium on Ceramics in Medicine. The Annual Meeting of the International Society for Ceramics in Medicine ; Conference date: 08-12-2004 Through 12-12-2004",
}