Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Matthias W. Lorenz; Horst Bickel; Michiel L. Bots; Monique M. B. Breteler; Alberico L. Catapano; Moise Desvarieux; Bo Hedblad; Bernhard Iglseder; Stein Harald Johnsen; Michal Juraska; Stefan Kiechl; Ellisiv B. Mathiesen; Giuseppe D. Norata; Liliana Grigore; Joseph Polak; Holger Poppert; Maria Rosvall; Tatjana Rundek; Ralph L. Sacco; Dirk Sander; Matthias Sitzer; Helmuth Steinmetz; Eva Stensland; Johann Willeit; Jacqueline Witteman; David Yanez; Simon G. Thompson

doi:10.1016/j.ahj.2010.02.008

Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Matthias W. Lorenz, Horst Bickel, Michiel L. Bots, Monique M. B. Breteler, Alberico L. Catapano, Moise Desvarieux, Bo Hedblad, Bernhard Iglseder, Stein Harald Johnsen, Michal Juraska, Stefan Kiechl, Ellisiv B. Mathiesen, Giuseppe D. Norata, Liliana Grigore, Joseph Polak, Holger Poppert, Maria Rosvall, Tatjana Rundek, Ralph L. Sacco, Dirk SanderMatthias Sitzer, Helmuth Steinmetz, Eva Stensland, Johann Willeit, Jacqueline Witteman, David Yanez, Simon G. Thompson

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Abstract

Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)

Original language	English
Pages (from-to)	730-U25
Journal	American Heart Journal
Volume	159
Issue number	5
DOIs	https://doi.org/10.1016/j.ahj.2010.02.008
Publication status	Published - 2010

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

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10.1016/j.ahj.2010.02.008

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Lorenz, M. W., Bickel, H., Bots, M. L., Breteler, M. M. B., Catapano, A. L., Desvarieux, M., Hedblad, B., Iglseder, B., Johnsen, S. H., Juraska, M., Kiechl, S., Mathiesen, E. B., Norata, G. D., Grigore, L., Polak, J., Poppert, H., Rosvall, M., Rundek, T., Sacco, R. L., ... Thompson, S. G. (2010). Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project. American Heart Journal, 159(5), 730-U25. https://doi.org/10.1016/j.ahj.2010.02.008

@article{d1bfe7dacf064ba49d850ac6a41d8a51,

title = "Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project",

abstract = "Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)",

author = "Lorenz, {Matthias W.} and Horst Bickel and Bots, {Michiel L.} and Breteler, {Monique M. B.} and Catapano, {Alberico L.} and Moise Desvarieux and Bo Hedblad and Bernhard Iglseder and Johnsen, {Stein Harald} and Michal Juraska and Stefan Kiechl and Mathiesen, {Ellisiv B.} and Norata, {Giuseppe D.} and Liliana Grigore and Joseph Polak and Holger Poppert and Maria Rosvall and Tatjana Rundek and Sacco, {Ralph L.} and Dirk Sander and Matthias Sitzer and Helmuth Steinmetz and Eva Stensland and Johann Willeit and Jacqueline Witteman and David Yanez and Thompson, {Simon G.}",

year = "2010",

doi = "10.1016/j.ahj.2010.02.008",

language = "English",

volume = "159",

pages = "730--U25",

journal = "American Heart Journal",

issn = "1097-6744",

publisher = "Mosby-Elsevier",

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Lorenz, MW, Bickel, H, Bots, ML, Breteler, MMB, Catapano, AL, Desvarieux, M, Hedblad, B, Iglseder, B, Johnsen, SH, Juraska, M, Kiechl, S, Mathiesen, EB, Norata, GD, Grigore, L, Polak, J, Poppert, H, Rosvall, M, Rundek, T, Sacco, RL, Sander, D, Sitzer, M, Steinmetz, H, Stensland, E, Willeit, J, Witteman, J, Yanez, D & Thompson, SG 2010, 'Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project', American Heart Journal, vol. 159, no. 5, pp. 730-U25. https://doi.org/10.1016/j.ahj.2010.02.008

TY - JOUR

T1 - Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

AU - Lorenz, Matthias W.

AU - Bickel, Horst

AU - Bots, Michiel L.

AU - Breteler, Monique M. B.

AU - Catapano, Alberico L.

AU - Desvarieux, Moise

AU - Hedblad, Bo

AU - Iglseder, Bernhard

AU - Johnsen, Stein Harald

AU - Juraska, Michal

AU - Kiechl, Stefan

AU - Mathiesen, Ellisiv B.

AU - Norata, Giuseppe D.

AU - Grigore, Liliana

AU - Polak, Joseph

AU - Poppert, Holger

AU - Rosvall, Maria

AU - Rundek, Tatjana

AU - Sacco, Ralph L.

AU - Sander, Dirk

AU - Sitzer, Matthias

AU - Steinmetz, Helmuth

AU - Stensland, Eva

AU - Willeit, Johann

AU - Witteman, Jacqueline

AU - Yanez, David

AU - Thompson, Simon G.

PY - 2010

Y1 - 2010

N2 - Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)

AB - Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)

U2 - 10.1016/j.ahj.2010.02.008

DO - 10.1016/j.ahj.2010.02.008

M3 - Article

C2 - 20435179

SN - 1097-6744

VL - 159

SP - 730-U25

JO - American Heart Journal

JF - American Heart Journal

IS - 5

ER -

Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Abstract

Subject classification (UKÄ)

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