Individualized closed-loop anesthesia through patient model partitioning

Ylva Wahlquist, Klaske van Heusden, Guy A. Dumont, Kristian Soltesz

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingResearchpeer-review

1 Citation (SciVal)
26 Downloads (Pure)

Abstract

Closed-loop controlled drug dosing has the potential of revolutionizing clinical anesthesia. However, interpatient variability in drug sensitivity poses a central challenge to the synthesis of safe controllers. Identifying a full individual pharmacokinetic–pharmacodynamic (PKPD) model for this synthesis is clinically infeasible due to limited excitation of PKPD dynamics and presence of unmodeled disturbances. This work presents a novel method to mitigate inter-patient variability. It is based on: 1) partitioning an a priori known model set into subsets; 2) synthesizing an optimal robust controller for each subset; 3) classifying patients into one of the subsets online based on demographic or induction phase data; 4) applying the associated closed-loop controller. The method is investigated in a simulation study, utilizing a set of 47 clinically obtained patient models. Results are presented and discussed.

Clinical relevance—The proposed method is easy to implement in clinical practice, and has potential to reduce the impact from surgical stimulation disturbances, and to result in safer closed-loop anesthesia with less risk of under- and over dosing.
Original languageEnglish
Title of host publication42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'20)
PublisherIEEE - Institute of Electrical and Electronics Engineers Inc.
Pages361
Number of pages4
DOIs
Publication statusPublished - 2020 Aug
Event42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - https://embc.embs.org/2020/, Quebec, Canada
Duration: 2020 Jul 202020 Jul 24

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology Society
PublisherIEEE
ISSN (Electronic)2694-0604

Conference

Conference42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated titleEMBC'20
Country/TerritoryCanada
CityQuebec
Period2020/07/202020/07/24

Subject classification (UKÄ)

  • Control Engineering

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