Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

Gottfrid Sjödahl; Kristina Lövgren; Martin Lauss; Gunilla Chebil; Oliver Hultman Patschan; Sigurdur Gudjonsson; Wiking Månsson; Mårten Fernö; Karin Leandersson; David Lindgren; Fredrik Liedberg; Mattias Höglund

doi:10.1016/j.urolonc.2014.02.007

Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

Gottfrid Sjödahl, Kristina Lövgren, Martin Lauss, Gunilla Chebil, Oliver Hultman Patschan, Sigurdur Gudjonsson, Wiking Månsson, Mårten Fernö, Karin Leandersson, David Lindgren, Fredrik Liedberg, Mattias Höglund

Research output: Contribution to journal › Article › peer-review

Abstract

Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.

Original language	English
Pages (from-to)	791-797
Journal	Urologic Oncology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/j.urolonc.2014.02.007
Publication status	Published - 2014

Subject classification (UKÄ)

Urology and Nephrology
Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.urolonc.2014.02.007

http://www.ncbi.nlm.nih.gov/pubmed/24794251?dopt=Abstract

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Sjödahl, G., Lövgren, K., Lauss, M., Chebil, G., Hultman Patschan, O., Gudjonsson, S., Månsson, W., Fernö, M., Leandersson, K., Lindgren, D., Liedberg, F., & Höglund, M. (2014). Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors. Urologic Oncology, 32(6), 791-797. https://doi.org/10.1016/j.urolonc.2014.02.007

@article{2ebd5007c07c475f9addab3c35bb3384,

title = "Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.",

abstract = "Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.",

author = "Gottfrid Sj{\"o}dahl and Kristina L{\"o}vgren and Martin Lauss and Gunilla Chebil and {Hultman Patschan}, Oliver and Sigurdur Gudjonsson and Wiking M{\aa}nsson and M{\aa}rten Fern{\"o} and Karin Leandersson and David Lindgren and Fredrik Liedberg and Mattias H{\"o}glund",

year = "2014",

doi = "10.1016/j.urolonc.2014.02.007",

language = "English",

volume = "32",

pages = "791--797",

journal = "Urologic Oncology",

issn = "1873-2496",

publisher = "Elsevier",

number = "6",

}

Sjödahl, G, Lövgren, K, Lauss, M, Chebil, G, Hultman Patschan, O, Gudjonsson, S, Månsson, W , Fernö, M , Leandersson, K , Lindgren, D , Liedberg, F & Höglund, M 2014, 'Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.', Urologic Oncology, vol. 32, no. 6, pp. 791-797. https://doi.org/10.1016/j.urolonc.2014.02.007

TY - JOUR

T1 - Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

AU - Sjödahl, Gottfrid

AU - Lövgren, Kristina

AU - Lauss, Martin

AU - Chebil, Gunilla

AU - Hultman Patschan, Oliver

AU - Gudjonsson, Sigurdur

AU - Månsson, Wiking

AU - Fernö, Mårten

AU - Leandersson, Karin

AU - Lindgren, David

AU - Liedberg, Fredrik

AU - Höglund, Mattias

PY - 2014

Y1 - 2014

N2 - Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.

AB - Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.

U2 - 10.1016/j.urolonc.2014.02.007

DO - 10.1016/j.urolonc.2014.02.007

M3 - Article

C2 - 24794251

SN - 1873-2496

VL - 32

SP - 791

EP - 797

JO - Urologic Oncology

JF - Urologic Oncology

IS - 6

ER -

Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

Abstract

Subject classification (UKÄ)

UN SDGs

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Cite this