Inflammatory Cytokines and Biomarkers of Cartilage Metabolism 8 Years After Anterior Cruciate Ligament Reconstruction: Results From Operated and Contralateral Knees.

Martina Åhlén; Leyla Roshani; Mattias Lidén; André Struglics; Lars Rostgård-Christensen; Jüri Kartus

doi:10.1177/0363546515574059

Inflammatory Cytokines and Biomarkers of Cartilage Metabolism 8 Years After Anterior Cruciate Ligament Reconstruction: Results From Operated and Contralateral Knees.

Martina Åhlén, Leyla Roshani, Mattias Lidén, André Struglics, Lars Rostgård-Christensen, Jüri Kartus

Orthopaedics (Lund)

Research output: Contribution to journal › Article › peer-review

Abstract

Patients who sustain an acute anterior cruciate ligament (ACL) rupture are at increased risk to develop posttraumatic arthritis (PTA) in the injured knee whether the ACL is reconstructed or treated nonoperatively. Inflammatory cytokines and cartilage degradation biomarkers are elevated at the time of acute injury and postoperatively. This suggests that one mechanism for PTA may be an inflammatory degradative process initiated on the acute injury and sustained for some length of time independent of whether adequate joint stability is restored.

Original language	English
Journal	The American journal of sports medicine
Early online date	2015 Mar 18
DOIs	https://doi.org/10.1177/0363546515574059
Publication status	Published - 2015

Subject classification (UKÄ)

Sport and Fitness Sciences

Access to Document

10.1177/0363546515574059

http://www.ncbi.nlm.nih.gov/pubmed/25787698?dopt=Abstract

Cite this

@article{aa19d62e9ecd4c34abe4d5dcdf21b048,

title = "Inflammatory Cytokines and Biomarkers of Cartilage Metabolism 8 Years After Anterior Cruciate Ligament Reconstruction: Results From Operated and Contralateral Knees.",

abstract = "Patients who sustain an acute anterior cruciate ligament (ACL) rupture are at increased risk to develop posttraumatic arthritis (PTA) in the injured knee whether the ACL is reconstructed or treated nonoperatively. Inflammatory cytokines and cartilage degradation biomarkers are elevated at the time of acute injury and postoperatively. This suggests that one mechanism for PTA may be an inflammatory degradative process initiated on the acute injury and sustained for some length of time independent of whether adequate joint stability is restored.",

author = "Martina {\AA}hl{\'e}n and Leyla Roshani and Mattias Lid{\'e}n and Andr{\'e} Struglics and Lars Rostg{\aa}rd-Christensen and J{\"u}ri Kartus",

year = "2015",

doi = "10.1177/0363546515574059",

language = "English",

journal = "The American journal of sports medicine",

issn = "1552-3365",

publisher = "SAGE Publications",

}

TY - JOUR

T1 - Inflammatory Cytokines and Biomarkers of Cartilage Metabolism 8 Years After Anterior Cruciate Ligament Reconstruction: Results From Operated and Contralateral Knees.

AU - Åhlén, Martina

AU - Roshani, Leyla

AU - Lidén, Mattias

AU - Struglics, André

AU - Rostgård-Christensen, Lars

AU - Kartus, Jüri

PY - 2015

Y1 - 2015

N2 - Patients who sustain an acute anterior cruciate ligament (ACL) rupture are at increased risk to develop posttraumatic arthritis (PTA) in the injured knee whether the ACL is reconstructed or treated nonoperatively. Inflammatory cytokines and cartilage degradation biomarkers are elevated at the time of acute injury and postoperatively. This suggests that one mechanism for PTA may be an inflammatory degradative process initiated on the acute injury and sustained for some length of time independent of whether adequate joint stability is restored.

AB - Patients who sustain an acute anterior cruciate ligament (ACL) rupture are at increased risk to develop posttraumatic arthritis (PTA) in the injured knee whether the ACL is reconstructed or treated nonoperatively. Inflammatory cytokines and cartilage degradation biomarkers are elevated at the time of acute injury and postoperatively. This suggests that one mechanism for PTA may be an inflammatory degradative process initiated on the acute injury and sustained for some length of time independent of whether adequate joint stability is restored.

U2 - 10.1177/0363546515574059

DO - 10.1177/0363546515574059

M3 - Article

C2 - 25787698

SN - 1552-3365

JO - The American journal of sports medicine

JF - The American journal of sports medicine

ER -

Inflammatory Cytokines and Biomarkers of Cartilage Metabolism 8 Years After Anterior Cruciate Ligament Reconstruction: Results From Operated and Contralateral Knees.

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Cite this