TY - JOUR
T1 - Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
AU - Lécuyer, Lucie
AU - Laouali, Nasser
AU - Dossus, Laure
AU - Shivappa, Nitin
AU - Hébert, James R.
AU - Agudo, Antonio
AU - Tjonneland, Anne
AU - Halkjaer, Jytte
AU - Overvad, Kim
AU - Katzke, Verena A.
AU - Le Cornet, Charlotte
AU - Schulze, Matthias B.
AU - Jannasch, Franziska
AU - Palli, Domenico
AU - Agnoli, Claudia
AU - Tumino, Rosario
AU - Dragna, Luca
AU - Iannuzzo, Gabriella
AU - Jensen, Torill Enget
AU - Brustad, Magritt
AU - Skeie, Guri
AU - Zamora-Ros, Raul
AU - Rodriguez-Barranco, Miguel
AU - Amiano, Pilar
AU - Chirlaque, María Dolores
AU - Ardanaz, Eva
AU - Almquist, Martin
AU - Sonestedt, Emily
AU - Sandström, Maria
AU - Nilsson, Lena Maria
AU - Weiderpass, Elisabete
AU - Huybrechts, Inge
AU - Rinaldi, Sabina
AU - Boutron-Ruault, Marie Christine
AU - Truong, Thérèse
PY - 2022
Y1 - 2022
N2 - Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period of 14 years, and 712 newly incident DTC cases were identified. Associations between four dietary inflammatory scores [the dietary inflammatory index (DII®) and two energy-adjusted derivatives (the E-DIIr and the E-DIId), and the Inflammatory Score of the Diet (ISD)] and DTC risk were evaluated in the EPIC cohort using multivariable Cox regression models. Results: Positive associations were observed between DTC risk and the DIIs (HR for 1 SD increase in DII: 1.11, 95%CI: 1.01, 1.23, similar results for its derivatives), but not with the ISD (HR for 1 SD increase: 1.04, 95% CI 0.93, 1.16). Conclusion: Diet-associated inflammation, as estimated by the DII and its derivatives, was weakly positively associated with DTC risk in a European adult population. These results suggesting that diet-associated inflammation acts in the etiology of DTC need to be validated in independent studies.
AB - Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period of 14 years, and 712 newly incident DTC cases were identified. Associations between four dietary inflammatory scores [the dietary inflammatory index (DII®) and two energy-adjusted derivatives (the E-DIIr and the E-DIId), and the Inflammatory Score of the Diet (ISD)] and DTC risk were evaluated in the EPIC cohort using multivariable Cox regression models. Results: Positive associations were observed between DTC risk and the DIIs (HR for 1 SD increase in DII: 1.11, 95%CI: 1.01, 1.23, similar results for its derivatives), but not with the ISD (HR for 1 SD increase: 1.04, 95% CI 0.93, 1.16). Conclusion: Diet-associated inflammation, as estimated by the DII and its derivatives, was weakly positively associated with DTC risk in a European adult population. These results suggesting that diet-associated inflammation acts in the etiology of DTC need to be validated in independent studies.
KW - Cohort
KW - Diet
KW - EPIC
KW - Inflammation
KW - Thyroid cancer
U2 - 10.1007/s00394-022-02897-w
DO - 10.1007/s00394-022-02897-w
M3 - Article
C2 - 35635567
AN - SCOPUS:85131095883
VL - 61
SP - 3625
EP - 3635
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6215
IS - 7
ER -